Sduty On The Therapeutic Effect Of Kidney Tonifying Essence Medicine On Male Infertility

Male infertility was first seen in the Jian Hexagram of Zhouyi,which appeared the words "pregnancy and infertility",and put forward the discussion of "men and women to marry fine,all things metaplasia." As a sick name,male infertility was not recorded in ancient Chinese medical books.The relevant discussion were scattered in"no child","less sperm","cold sperm","impotence".Chinese medicine believe that the kidney main reproduction,doctor of traditional Chinese medicine cure male infertility starting from the kidney most of the time.Modern medicine think that among many causes of male infertility,decreasing in sperm concentration(spermatozoa)and sperm motility(weak sperm)are common factors,which often appear together being called Oligoasthenospermia.Spermatozoa refers to sperm concentration<15 X 106/ml,and meet the number of shot sperm<39 × 106;weak sperm disease refers to sperm concentration ? 15 × 106/ml,while the forward movement sperm<32%,and sperm total activity<40%.This paper studies the mechanism of the treatment of male infertility.On the basis of sorting Chinese medicine literature systematically,this paper studies from the traditional Chinese medicine theory,modern clinical and experimental research,and discusses clinical application of traditional Chinese medicine.By arranging ancient Chinese medical books and clinical reports of calendar year,this article explores the physiological pathology and treatment law of male infertility in Chinese medicine.Kidney stores essence and main reproduction,main essence chamber.Loss of kidney essence is the basic pathogenesis of male infertility.It can lead to loss of kidney essence if lacking of inherent endowment,the excessive fatigue,long illness unhealed or indulgence,triggering infertility in the end.And can appear kidney yang deficiency or kidney yin deficiency syndrome.Liver mains catharsis,emotional failure or liver qi stagnation can can cause impotence and infertility;liver qi stagnation long can also consump essence and blood lead to kidney essence loss and infertility.Spleen main transport,is the foundation of acquired constitution.The living impermanence or too much thinking can hurt spleen and stomach so that kidney essence can not fully be supported.If spleen deficiency for a long time,the phlegm dampness will breed.Phlegm and dampness stagnated heat and dampness heat disturbing essence chamber can also cause infertility.Kidney tonifying essence medicine mainly effect into the kidney channel,having the effect of tonifying the kidney essence.Kidney tonifying essence medicine warm can warm kidney Yang,raise the essence,the medicine cold can tonify kidney Yin,clear heat.Kidney essence loss is the basis of male infertility,the use of kidney tonifying essence medicine can achieve good clinical efficacy.We use the effective prescription Jingqi Capsules of our tutor to study the protective effects of kidney tonifying essence medicine on the damage to rat reproductive system induced by cyclophosphamide in the experimental study.Jingqi Capsules can increase the level of serum testosterone and organ coefficient of testis,epididymis and prostate(p<0.05,p<0.01).HE showed the Jingqi treatment group can relieve the damage to seminiferous epithelium and increase the number of all spermatogenic cells compared with the model group.CASA showed Jingqi treatment group can increase sperm count(p<0.01)and sperm motility(p<0.001).TUNEL showed the positive expression and the average light density were decreased in the Jingqi treatment group(p<0.01),indicated that the Jingqi Capsules has anti apoptotic effect.The reseach shows Jingqi Capsules has protective effects on damage to rat reproductive system.The results of this study provide an experimental basis for the clinical application of kidney tonifying essence medicine in the treatment of male infertility.