Expression And Clinical Significance Of P53 And Survivin In Oral Lichen Planus And Oral Squamous Cell Carcinoma

Background: Oral lichen planus is a chronic inflammatory disease with stratified squamous epithelium.The mucosa symptom and the skin symptom can appear alone or at the same time.Oral lichen planus has been defined as a precancerous lesion by the WHO,because it has a higher tendency of malignant transformation than normal tissues.And its canceration rate is from 0.4% to 2%.Oral squamous cell carcinoma is the most common malignant tumor among oral and maxillofacial region,accounting for 90% of all the oral tumor,and the survival rate among 5 years is only 35% to 50%.It is a lesion of high malignant degree,strong local invasion,early lymph node metastasis and poor prognosis.P53 is an important tumor suppressor gene,and the mutation of p53 gene is found in more than half of human tumor tissues,such as esophageal cancer,breast cancer,bladder cancer,liver cancer and cervical cancer.Among the members of the inhibitor of apoptosis protein family,the relative molecular mass of survivin is the minimal and its function of apoptosis inhibition is the most powerful.Survivin is associated with proliferation,angiogenesis,oral carcinogenesis and oral squamous cell carcinoma and probably as a biomarker for cancer.Objectives: By detecting the expression of p53 protein and survivin protein in oral lichen planus and oral squamous cell carcinoma,we discuss the correlation between p53 protein and survivin protein and analyze the role of p53 protein and survivin protein in the development from normal oral mucosa,oral lichen planus to oral squamous cell carcinoma.Methods: The experiment adopts immunohistochemistry method to detect the expression of p53 protein and survivin protein in 12 cases of normal oral mucosa tissues,30 cases of oral lichen planus tissues and 30 cases of oral squamous cell carcinoma tissues.The experimental specimens are from biopsy or surgical specimens in surgery.Finally we analysis the results with SPSS software.Results: 1.The positive expressions of p53 protein in normal oral mucosa,oral lichen planus and oral squamous cell carcinoma increase in turn.The positive rates respectively are 16.67%(2/12)? 53.33%(16/30)?80.00%(24/30).The differences between groups are statistically significant(p < 0.05).2.The positive expressions of survivin protein in normal oral mucosa,oral lichen planus and oral squamous cell carcinoma increase in turn.The positive rates respectively are 0%(0/12)? 26.67%(8/30)?56.67%(17/30).The differences between groups are statistically significant(p < 0.05).3.The expressions of p53 protein and survivin protein are significantly positive correlation(p<0.01).Conclusions: 1.The positive expressions of p53 protein in normal oral mucosa,oral lichen planus and oral squamous cell carcinoma increase in turn.P53 protein plays a promoting role in the development from normal oral mucosa,oral lichen planus to oral squamous cell carcinoma.2.The positive expressions of survivin protein in normal oral mucosa,oral lichen planus and oral squamous cell carcinoma increase in turn.Survivin protein plays a promoting role in the development from normal oral mucosa,oral lichen planus to oral squamous cell carcinoma.3.The expressions of p53 protein and survivin protein are positively correlated in the process of oral lichen planus canceration.We speculate they may cooperate with each other in the process from oral lichen planus to oral squamous cell carcinoma.