Assessment Of Nutritional Status And Its Influence Factors In Tumor Patients

Backgroud Increasing evidence supports the involvement of systemic nutritional status in cancer progression.Recently the incidence rate of malignancy has been emergeing at an ascending tendency and the malignant patients ususally sufferers a high incidence of malnutrition.Malnutrition is emerging as a significant factor in patient outcomes and there do exsit large amounts of patients die of nutritional impairment element rather than the cancer itself.According to incomplete statistics,approximately more than two million cancer patients die of severe malnutrition.Hence,here the aim of our research was to assess the nutriture state of cancer patients and analysis related factors by employing the most commonly used method of patient-generated subjective global assessment at home and abroad.Meanwhile,we explored the practicability and feasibility of the method of PG-SGA and provided a basis for malignancy sufferer' proper intervention and support.Objective To evaluate the nutritional status of tumor patients in the department of radiotherapy and chemotherapy of Anhui Provincial Tumor Hospital with the patient-generated subjective global assessment(PG-SGA)and to analyze the factors that affect malnutrition in cancer patients.Methods 996 tumor patients from the department of radiotherapy and chemotherapy of Anhui Provincial Tumor Hospital were recruited from Feb 1th,2014 to Aug 31 th,2016.Patients' nutritional status was evaluated by PG-SGA scale and according to the result was graded into good nutrition(PG-SGA A)group,suspected or moderate malnutrition(PG-SGA B)group,severe malnutrition(PG-SGA C)group.Objective thebasic information of patients and nutritional indicators were collected on admission.Analysis of the relationship between various factors and malnutrition.Results1.In this study,959 patients with malignant tumors were included.Among them,those who underwent stage A of PG-SGA method are 366(38.16%),stage B are 268(27.95%),stage C are 325(33.89%),with total incidence of malnutrition are 61.84%.In detail,the incidence of this set data in order is gastric carcinoma(83.22 %),esophageal cancer(78.53%),colorectal cancer(55.29%),cervical cancer(51.66%),lung cancer(51.11),breast cancer(40.30%).2.Multivariate logistic regression analysis showed that gender [odds ratio(OR)=0.164,P=0.000,95% confidence interval(95%CI)0.097-0.279],age(OR=0.958,P=0.000,95%CI0.940-0.975),radiotherapy(OR=1.629,P=0.031,95%CI 1.045-2.541),xerostomia(OR=0.038,P=0.000,95%CI 0.008-0.192),body mass index(OR=11.769,P=0.000,95%CI 5.766-24.023),hypoalbuminemia(OR=10.982,P=0.006,95%CI2.022-59.661),early satiety(OR=0.053,P=0.000,95%CI 0.011-0.261)the grip strength(OR=1.060,P=0.000,95%CI 1.060-1.130),were independent risk factors of malnutrition in patients with malignant tumor.Conclusions1.The method of PG-SGA is a proven reliable and widespread survival predictor for the evaluation of nutriture in malignant tumor patient.Here,we strongly recommend PG-SGA should used in routine clinical and it would play an important role in the treatment of patients admitted to hospital.2.It is necessary for patients with malignant tumor,especially in the digestive tract cancer sufferers,to evaluation and support nutrition intervention as early as possible.3.Due to the influential factors is complicated and various,we should pay more attention and focus on risk factors of malnutrition,so as to achieve early realization of thetumor patients and provide individualized,standardization of nutritional intervention and supporting therapy.As the mechanism of malnutrition is not yet fully clear,we need to continue to explore in the future.