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Application Of A Amide-supported Catalyst And Synthesis Of A Mercury Ion Fluorescent Probe

Posted on:2018-11-05Degree:MasterType:Thesis
Country:ChinaCandidate:Z Y WangFull Text:PDF
GTID:2351330515980692Subject:Organic Chemistry
Abstract/Summary:PDF Full Text Request
Mesoporous silica materials with ordered porous structure,adjustable pore size,controllable morphology make it become an effective catalyst support;especially the construction of mesoporous silica materials with hydrophilicity as catalyst,plays an important role in the catalytic reaction,which not only can improve the dispersion of reaction system in water,increase the reaction speed,and can be used repeatedly.In the first part of this paper,Sulfinamide squaramide catalyst was connectede on hydrophilic mesoporous silica materials through the click chemistry strategy,then we got chiral Squaramides supported catalyst.And successfully applied it to asymmetric Michael addition reaction of water medium.Mercury ion(Hg2+)is one of the most toxic heavy metals.Therefore,it is of great significance for the selective recognition of mercury ions.Among the many methods for detecting heavy metal ions,fluorescent probes have attracted many researchers' attention because of their high accuracy,sensitivity and specificity.Enlarging the application range of the fluorescence probe and simplifying the probe condition is the main direction of optimization.?1?In the first part of this paper,transesterification happened with polyethylene glycol monomethyl ether and hyperbranched poly ethoxy silane,hydrophilic polymer precursor was prepared.The polymer precursor copolymerized with functional silicon source,3-mercapto propyl triethoxysilanethe,assembled thiol-functionalized mesoporous silica nanoparticles.finally connected organic small molecule catalyst Squaramides through the click reaction on materials,preparing chiral Squaramides catalyst with vesicles and spherical structure supported.Applying the catalyst in the asymmetric Mike addition reaction of acetylacetone and nitro olefin as substrate showed good catalytic activity?conversion rate as high as 99%?and enantioselective?chiral value as high as 97%?,at the same time,the catalyst can be recycled with simple operationf of centrifugation and reused for 8 times with catalytic activity remains high.?2?In the second part of this paper,we designed and synthesized a new kind of mercury ion fluorescent probe which is based on the BODIPY as the fluorescence group and hydrazine as the active group.The probe can complete the detection of mercury ion in 5 minutes in aqueous solution.In aqueous solution of the probe,with the increase of the concentration of the mercury ion solution,UV absorption showed a red shift and fluorescence intensity is greatly enhanced;even very low concentrations of mercury ions?0.1 ?M?also can significantly enhanced the fluorescence intensity of the system,explaining its good sensitivity.In addition,it was found that the probe had no obvious response to other common metal ions under the same conditions,it shows that the probe has good selectivity.
Keywords/Search Tags:Mesoporous silica material, self-assembly, Small molecule catalyst, Mercury ion, fluorescence probe, BODIPY
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