Research On Dachaihu Tang Syndrome Based On Data Mining

ObjectiveOn the basis of summarizing the understanding of the relevant provisions of Dachaihu Tang prescription,combined with the exposition of ancient physicians,clear the etiology and pathogenesis of Dazhuai decoction and its prescription.And the statistical analysis of modern medical records,summed up the comparison of Dazhuai Tang adaptable diseases,symptoms,signs and drug composition and so on.Finally,the meta-analysis method was used to evaluate the clinical curative effect of Dachaihu Decoction and its addition and subtraction in the treatment of acute cholecystitis.Through the clinical randomized controlled trials of Dachaihu Decoction in the treatment of acute cholecystitis,the clinical trials of Dachaihu Decoction were evaluated in an objective and systematic manner,and the results were obtained as far as possible.MethodsTheoretical research,the first to "Treatise on Febrile Diseases" and "Golden Chamber" recorded in the provisions of the prescription as the basis,through the prescription,the etiology and pathogenesis,disease,prescription,decoction and other aspects of Dabaihu Decoction recipe analysis,making the rationale for a consistent prescription.Secondly,for the ancient physicians' s research about Dabaihu Decoction' s pathogenesis and there is discussiong about whether a Dahuang is in the prescription.And we will get an objective understanding of its disease and the composition of the prescription.Thirdly,compared with other Bupleurum Decoction,we will have a systematic and definite knowledge about the position and function of Dachaihu Decoction in Bupleurum Decoction,which provides the theory for the proper use of Dachaihu Decoction.Clinical medical study of statistical analysis,through the collection of modern clinical application of the 100 cases of Dachaihu Decoction,summarized the treatment of the disease,symptoms,drug composition,drug dose,the number of agents,the patient' s gender age,the use of statistics method to obtain the side of the clinical treatment of the scope of the disease.Meta analysis,Dachaihu Tang and its addition and subtraction in the treatment of acute cholecystitis system evaluation,due to the lack of large sample of multi-center randomized controlled trials,the study of Dachaihu Tang recipe focused on small sample of clinical research or case reports.In order to evaluate the effect of Dachaihu Decoction in the treatment of specific diseases,the authors searched the database:Chinese Journal Full-text Database(CNKI),Vipu Chinese Science and Technology Full-text Database(VIP),Chinese Biomedical Literature Database(CBM)1949-2016.6 related literature,the database did not retrieve the literature by hand to be added.Search words:In order to prevent the leakage of the same purpose of the study of the literature,set the keywords 3:Da Chai Hu Tang,compound Da Chai Hu Tang,Da Chai Hu soup addition and subtraction.Key words:acute cholecystitis.373 articles were searched by computer.After reading,sorting and sorting,each document was recorded according to the two tests in the Cochrane literature quality evaluation system,and the information on the high risk of bias was removed.Literatures were used to evaluate the existing randomized controlled trials using Revman5.3 software.Results:First,combined with Liujing,Liujing Disease,Liujing Dialectical and other concepts and the ancient physician for the understanding of Dabaihu Tang,draw Dabaihu Tang disease in Shaoyang Yangming,the pathological level involved in camp blood points.Second,through the medical statistics study Dachaihu Tang in the application of the population with specificity,frequently in the elderly,but the clinical regardless of age,as long as consistent with the side of the symptoms,you can use as appropriate.This side of the clinical widely used in liver and spleen and stomach digestive diseases,lung disease and other diseases,the application of the main indications for the constipation,urine yellow,abdominal pain,nausea,flank pain,fever,irritability,Pulse number and other symptoms,the main components include Bupleurum,Scutellaria,rhubarb,citrus aurantium,France Pinellia,jujube,ginger,white peony and so on.Effective and reliable,worthy of extensive promotion.Third,two classification variables:Da Chai Hu Tang VS Western routine treatment:efficiency:OR(Total)= 5.15,95%CI[1.86,14.26],Z = 3.16,P =0.002;RR(total)= 1.17,95%CI=1.05,P = 0.0010;RD(total)= 0.14,95%CI[0.06,0.22],Z = 3.51,P = 0.0004 Cure rate:OR(total)= 2.55,95%(Total =0.17,95%CI[1.15,1.88],Z = 3.05,P = 0.002;RD(total)=0.19,95%CI[1.41,4.63],Z = 3.09,P = 0.002;0.06,0.30),Z = 3.24,P = 0,001;Dachaihu Decoction+ Western routine treatment of conventional western medicine treatment:effective rate:OR(total)= 4.95,95%CI[3.67,6.69],Z = 10.43,0.001;RD(total)= 0.16,95%CI[0.13,0.18],1 = 11.56,P<0.00001;RR(total)= 1.20,95%CI[1.16,1.24],Z = 10.68,The total cure rate:OR(total)= 2.10,95%CI[1.77,2.51],Z = 8.36,P<0.00001;RR(total)= 1.40,95%CI[1.29,1.51],Z= 8.19,;RD(total)=0.17,95%CI[0.13,0.21],Z = 8.62,P<0.00001.Continuity variable:Da Chai Hu Tang VS Western medicine routine treatment:abdominal pain disappeared:SMD(total)?-1.05,95%CI[-1.37,-0.72],Z=6.33,P<0.00001;Fever subsided time SMD(total)=-0.84,95%CI[-1.15,-0.52],Z = 5-19,P<0.00001;Dachaihu Decoction + Western routine treatment of Western medicine conventional treatment:abdominal pain disappeared:SMD(total)=-2.47,95%CI =-3.39,-1.56],Z = 5.32,P<0.00001;fever regression time:SMD(total)=-2.22,95%Cl[-3.13,-1.31],Z = 4.78,P<0.00001;Time = SMD(total)=-0.47,95%CI[-0.80,-0.13],Z = 2.73,P = 0.006;nausea and vomiting disappeared:SMD(total)=-2.39,95%CI[-2.74,2.04],Z = 13.50,P<0.00001.Conclusion:Dachaihu Decocation is in the gas and blood disease of Shaoyang Yangming and there is heat blood hurt of pathology development changes.Dachaihu Deco cation syndrome to adapt to the disease mainly contains liver and gallbladder stomach digestive system diseases,lung disease.The common symptoms and signs of constipation is urine yellow,abdominal pain,nausea,flank pain,fever,irritability,red tongue,yellow Chord number and other symptoms.The age of onset mainly concentrated in the elderly.Dachaihu Decoction in the treatment of acute cholecystitis effective rate,cure rate is better than conventional Western medicine treatment.This approve that Dachaihu Decocation have unparalleled advantages to improve abdominal pain,fever time,jaundice,nausea and vomiting and other symptoms.