Study On Synthesis,Antibacterial Activity Of 5-Fluorosalicylaldehyde Schiff Bases And Their Metal Complexes

In this dissertation,two new Schiff base ligands were synthesized from5-fluorosalicylidene amantadine derivatives,and six new complexes containing tran-sition metals copper,cobalt and zinc were synthesized under suitable conditions.The ideal single crystals for the six complexes were obtained.A series of characterization were carried out on the compounds obtained in this paper.The details are as follows:1.Two new Schiff base ligands HL~1,HL~2 were synthesized respectively from5-fluorosalicylaldehyde with memantamine and 3-amino-1-adamantanol,then three new metal complexs 1,2,3 were synthesized respectively from the reactions of HL~1with copper chloride dihydrate,cobalt chloride hexahydrate and anhydrous zinc chlo-ride in the presence of NaOH with methanol as solvent under the condition of 60?.With HL~2 as ligand,another three new complexes 4,5,6 were synthesized according to the same steps above.2.The ligands and complexs synthesized above were characterized by several testing methods,including melting point,infrared spectra,ultraviolet-visible spectra,~1H-NMR and X-ray diffraction.The single crystal of six complexes were obtained and the X-ray single crystal diffraction test were carried out respectively to determine the structure of the complexes.3.The antibacterial activity of the two ligands and six ligands against Staphylo-coccus aureus,Escherichia coli,Bacillus subtilis and Penicillium was tested.It was found that the antibacterial properties of the complexes were stronger than the corre-sponding ligands.Moreover,the antibacterial activity of zinc complexes were strong-er than that of copper and cobalt complexes.