Analysis Of Clinical Characteristics And Risk Factors Of Adverse Transfusion Reactions In Children

Research backgroundBlood transfusion is a double-edged sword,children's physiological and biochemical and immune hematology is special,blood components are complex,so in the course of blood transfusion prone to varying degrees of transfusion reaction,such as fever,allergic reactions,acute lung injury,inflammation and venous blood disease,patients need long-term repeated transfusion,increased the incidence of adverse transfusion reactions,exacerbations obvious,even life-threatening.Due to differences in the severity of the transfusion reaction is large,so the analysis of the clinical characteristics of children with blood transfusion adverse reactions of blood transfusion,and has great significance to formulate the corresponding preventive measures can reduce the incidence of adverse reaction in blood transfusion were largely.Objective1.To analyze the basic situation of all children who received blood transfusion in the past 1 years,and to provide reference data for clinical reasonable and standard blood transfusion To investigate the prevention of transfusion adverse reactions in children with blood transfusion.2.To analyze the incidence of transfusion reaction,the main clinical manifestations and the type of blood transfusion reaction in our hospital in recent years.Method1.The methods of case collection:16091 transfusion cases were selected in Children's Hospital Affiliated to Medical University Of Chongqingfrom October 2015 to October 2016,and There were 213 children who had a transfusion reaction.2.Research method : To analys the children's data with the method of retrospective analysis,analysis of its Age,sex,blood transfusion,blood transfusion,the clinical data of blood transfusion reaction,transfusion reaction type and blood group were statistically analyzed,and the effects of risk factors(age,number of transfusion,blood components,etc.)on the incidence of transfusion reaction were analyzed,and the corresponding preventive measures were discussed.3.Statistical analysis methods: This study used SPSS19.0 statistical software to analyze the data,enumeration data are expressed in frequency or rate were compared by chi square test,P< 0.05,the results were statistically significant.Result1.Patients in our hospital in the year 16091 cases of transfusion treatment,the total number of children receiving blood transfusion of 3980 people,In addition to albumin,gamma globulin and other blood products,a total infusion of red blood cell 8353 U,plasma 572950 ml,5845U,26030 U,The transfusion of red blood cells in the blood transfusion was the highest,reaching 9184 people(57.08%).In the age distribution of patients receiving blood transfusion,the number of patients in the 0-3 years old group was the highest,reaching 8445 passengers,accounting for 52.48%,The majority of male patients receiving blood transfusion treatment,up to 9540 passengers,accounting for 59.29%,The three departments with the most blood transfusion treatment were department of Hematology 6795 times(42.23%),Critical care medicine 3943(24.50%),1750 cases of neonatal(10.88%),Blood type distribution of blood transfusion in children with type AB transfusion was significantly less than the A type,B type,O type of person;children in the transfusion of blood transfusion therapy in children with common.2.Our hospital a total of 213 blood transfusion reactions occurred in the year,a total of 148 people,the total incidence of transfusion reaction was 1.32%,mean age(6.31±1.03)in children with transfusion reactions,and most of the children were 3-12 years old,The male patients with transfusion reaction were 121 cases,accounting for 56.81%;transfusion reaction were repeatedly transfusion common;transfusion reaction with platelets in most people,up to 164 cases,accounting for 77%.3.In this study,children with transfusion reactions were mainly non hemolytic fever,non hemolytic fever with allergic reactions,allergic reactions,allergic reactions to the main,up to 193 cases,accounting for 90.61%.4.The clinical manifestations of children with skin rash wheals transfusion reaction with itching,edema,cough and throat discomfort,dyspnea,fever,vomiting,abdominal pain,diarrhea,severe cases of anaphylactic shock,including skin rash,local skin itching and local edema skin allergic symptoms.5.There was significant difference in the incidence of transfusion reaction in different age groups,and the incidence of transfusion reaction was higher in children aged 7-12 years.6.The blood transfusion reaction of the children who received multiple blood transfusion therapy was the majority,and the incidence of transfusion reaction caused by different times of blood transfusion was statistically different.7.There was significant difference in the incidence of adverse reactions caused by different transfusion components,and the incidence of transfusion reaction caused by platelet transfusion was relatively high.Conclusion1.The annual blood transfusion treatment cases in large quantities,the infant group blood transfusion group most,blood transfusion of older less;Department of Hematology,ICU and neonatology department is the largest blood transfusion;male patients received a blood transfusion in children than women.2.The incidence of transfusion reaction in children was higher,and the risk of transfusion could not be ignored.The types of transfusion reactions in children included non hemolytic fever,allergic reaction,non hemolytic fever and allergic reaction 3.The clinical manifestations of transfusion reactions to allergic reactions,including wheal with itching,rash and other skin symptoms common local edema,also can appear difficulty breathing and shock.4.The age of children,the history of blood transfusion,platelet,leukemia and aplastic anemia were the main risk factors of transfusion reaction.