Research On Preparati On Quality,Specification And Efficacy Evaluation Of Shensongsoft Capsule

Developed Shensong soft capsule which composed with ginseng,propolis,seabuckthorn oil,and pine pollen,to alleviate the sub-health state by reason of the serious environmental pollution and life pressure increasing,the most common symptoms of sub-heslth state such as immunological deficiency.It is mainly used to enhance the body’s immune ability.The four kinds of all belong to edible chinese herbal.for purpose of covering up the bad smell and taking easily.Wrap up pine pollen,seabuckthornl oi and the extract of ginseng and propolis,into soft capsule,but also improving the bioavailability.This study included:the optimum extraction process of ginseng and propolis,preparing soft capsule,formulate its quality criteria.In this thesis,the content of ginseng total saponin as indexes to optimize the ethanol concentration,frequency of extraction,the extraction time and the solvent volume to be the examine factors,each factor set up three levels orthogonal experiment method and the optimization of the extraction process of ginseng.The content of ginseng saponin is determined by uv-vis-spectrophotometry,in order to optimum extraction process of ginseng is concentration of 70%ethanol,10-fold liquid,extracting 2 times,3 hours per time.According to the literature,propolis tend to dissolve in organic solvent,Lead level of propolis,that is extract by 70%ethanol,is less than 1 mg/kg,which is qualified.Excellent-compatibility with glycerol gelatin material,is widely used in the soft capsule preparation of plasticizer,spread to the skin more soft capsule,no deformation.Therefore this product using glycerol as plasticizer.In the capsule shell preparation process,factors set the ratio of gelatin and glycerin,gelatin and water ratio,sol temperature,set up three levels of each factor,lemon yellow as indicator,rate as the index the dissolution of capsule,designed by orthogonal test method.Detemine the capsule recipe is glycerinum:water:gelatin＝3:5:5,and under the condition of 85℃.Through the observation of the contents of the viscosity,liquidity and uniformity of distribution,determine the best ratio of materials to liquor is 1:1.5.When beeswax account for 4%of material proportion is steady the system.Ginseng,propolis,seabuckthorn oil in the prescription were qualitative identified by TLC method,the morphological identification of broken pine pollen scanning by electron microscope.The content of Re,Rbl,Rgl in ginseng and Shensong soft capsule determined by HPLC.UV-vis-spectrophotometry determine content of total flavonoids in ginseng soft capsules,and it’s not less than 0.6%.Capsules are all collapse within 1 h.Marked the load for:0.5 g/grain,tested each grain filling quantity differences are within ±10%.Preliminary study on the stability of three batch samples to,normal temperature retention samples experiments did not change significantly the indicators and comply with regulations,quality is stable and controllable.Efficacy studies found that Shensong soft capsule had no impact on the weight,organ coefficient,DTH,and the carbon clearance indexes.Medium and high dose group has the function of that the cellular immunity of mice.Medium and high dose of ginseng soft capsule on mice humoral immune function test of the two features have obvious enhancing effect.This research improve the preparation method of herbal,optimized the extraction and preparation technology,strengthening quality control,and to determine the function.And soft capsule of four kinds of medicinal herbs in Shensong soft capsule all belong to chinese edible herbal And Shensong soft capsule is content accurately,has high bioavailability,stability,as well as many advantages.