The Effect On Hyperlipidemia Rats In Components Of Erythrocyte Membrane By Using Buyang Huanwu Decoction,shaofu Zhuyu Decoctionand Danshen Decoction

Objectives:Copy the rat model of hyperlipemia,and were given for Buyang Huanwu decoction,Shaofu Zhuyu decoction,Danshen decoction.With the established biological characteristics of erythrocyte membrane research platform around RBCM biological characteristics of the model changes were observed biological changes characteristic three first prescriptions for hyperlipidemia model RBCM caused.Hyperlipidemia treatment of new mechanisms,hyperlipidemia clear differences in red blood cell membrane.Methods:As the rat study,oral administration of lipid emulsion to replicate rat model hyperlipemia,and were orally administered Buyang Huanwu decoction,Shaofu Zhuyu decoction,Danshen decoction and the positive control drug simvastatin statins.Continued modeling for 20 days,drug treatment 10 days,fed fat emulsion treatment while continuing to maintain the state hyperlipemia.Carotid artery blood whole blood viscosity,plasma viscosity,coagulation,serum lipids four items;the red blood cell membrane preparation,testing erythrocyte membrane Na+-K+-ATP enzyme activity,SA,mercapto group,SOD,MDA.Results:Compared with the control group,was significantly increased in model group TG,CHO,LDL-C,GLU content(P<0.01),HDL-C levels decreased significantly(P<0.01);whole blood viscosity at 3 s-1,30 s-1,60 s-1,at 200 s-1 shear rate was significantly higher(P<0.05 or P<0.01),was significantly increased(P<0.01)plasma viscosity;APTT model group was significantly shorter(P<0.01),PT significantly reduced(P<0.05),significantly elevated FIB(P<0.01);Na+-K+-ATP activity,sialic acid,a thiol group content has significantly reduced(P<0.05),SOD content decreased significantly(P<0.05),MDA content was significantly higher(P<0.05).Compared with the model group,the three parties can be on TG,CHO,LDL-C,GLU content have lower(P<0.05 or P<0.01),the content of HDL-C have increased(P<0.05 or P<0.01);Danshen decoction to whole blood viscosity at 3 s-1,30 s-1,60 s-1,200 s-1 shear rate was significantly higher(P<0.05),Buyang Huanwu decoction on whole blood viscosity at 3 s-1,30 s-1,at 200 s-1 shear rate was significantly higher(P<0.05),Shaofu Zhuyu decoction on whole blood viscosity at 3 s-1,30 s-1,60 s-1 shear rate significantly increased(P<0.05 or P<0.01),plasma viscosity constituents can be reduced(P<0.05 or P<0.01);Danshen decoction administration group APTT,PT was significantly longer(P<0.05),FIB decreased significantly(P<0.05),Buyang Huanwu decoction administration group APTT,PT was significantly longer(P<0.05),FIB decreased significantly(P<0.05),APTT Shaofu Zhuyu decoction administration group was significantly longer(P<0.05),significantly decreased FIB(P<0.05);Danshen decoction of Na+-K+-ATP activity,the content of mercapto group has increased significantly drink administration group(P<0.05),the content of SOD was significantly increased(P<0.05),the content of MDA decreased significantly(P<0.05);Buyang Huanwu decoction Na+-K+-ATP activity,SA,mercapto group of content has increased significantly(P<0.05),the content of SOD increased significantly(P<0.05);Shaofu Zhuyu decoction on the content of SA and mercapto group has significantly increased(P<0.05),the content of SOD was significantly increased(P<0.05).Conclusions:1.The three parties are on blood lipid and blood sugar levels four hyperlipidemic rats significantly change the role,reduce blood viscosity and plasma viscosity.2.Tripartite significant change coagulation function in rats hyperlipemia,extend APTT,PT,reduce FIB.3.tripartite significant changes to the component of red blood cell membrane in rats with hyperlipidemia,red blood cells have a protective effect.