| Object:Study the effects of the Kangfuxinye totreatment endometrium infertilityMethodIn this study,non-randomized non-blinded.Collected in Chengdu University of Traditional Chinese Medicine First,Second Afiliated Hospital of TCM gynecology clinic thin endometrium infertility or history of spontaneous abortion(syndrome of static blood blocking in uterus)from 2015.2 months to 2016.4.Divided into 2 groups?Oral low dose(10ml,qd-tid)Kangfuxin was used as a control group ?High-dose group were treated Kangfuxin solution 30ml,tid Weekly review B,After ovulation,or during menstruation is not stopping contraception,menstrual cycle as a course of treatment was observed 1-2 Combined with traditional Chinese medicine syndrome differentiation,Spleen weak(sijunzi),Kidney yang deficiency(youguiwan),Kidney yin deficiency(huanglianejiaotang)Decoction,one a day,three times a day.Philips HD 15 color Doppler ultrasound systems,high-frequency probe center frequency of>7.5 MHz.Measuring the luteal phase(7 days after ovulation to premenstrual)endometrial thickness,endometrial lower blood supply.Using Roche COB AS E411 electrochemical measuring instrument and kit luteal phase E2,P.Low dose group and large dose group before and after treatment luteal phase endometrial thickness,endometrial lower blood supply,E2,P changes.Analysis of high-dose group before and after treatment of TCM syndrome,TCM symptom score,pregnancy,luteal phase endometrial thickness,endometrial lower blood supply,E2,P changes.Application SPSS21.0 statistical software for statistical analysis..ResultThe study included thin endometrium infertility or spontaneous abortion history of 57 patients.Low-dose group,25 cases were observed 25 courses;high dose group of 32 patients were observed 46 courses.Two groups of age(34.04 ± 6.09,33.33 ± 5.77)years,duration(2.88 ± 3.30,2.43 ± 2.90),the number of pregnancy(abortion views 27,35;21,31 spontaneous abortion views;IVF-ET pregnancy failure 18,25)showed no significant difference,P>0.05.1.After the high-dose treatment group luteal phase endometrial thickness(5.73 ±1.61mm,7.38 ± 1.67mm,P<0.05)increased significantly lower dose group(6.38 ?2.22mm;6.42 ± 1.58mm,P>0.05),P<0.05.Tip Kangfuxin high dose may be increased in patients with thin endometrium endometrial thickness.2.After the high-dose treatment group luteal phase endometrial blood flow RI(0.58 ? 0.14)than before treatment(0.69 ± 0.21)decreased,P<0.05;low dose group before and after treatment(0.80 ± 0.43,0.57 ± 0.11,P>0.05),between the two groups after treatment,the difference was not statistically significant(P>0.05).Tip high dose Kangfuxin can reduce endometrial blood flow RI.3.After the high-dose treatment group luteal phase E2,P(180.43 ± 54.06,177.65± 89.87)(15.75 ± 5.99,16.32 ± 5.77),low-dose group luteal phase E2,P(183.54 ±91.88,159.66 ? 70.21)(12.74 ± 7.46,12.84 ± 6.31)comparison,P>0.05;between the two groups after treatment,P>0.054.After the high-dose treatment group of 32 patients temporary contraception or row frozen embryo transplant patients with 7 cases.25 patients a total of nine cases of pregnancy(FET 1 case of pregnancy,spontaneous pregnancy eight cases),3 cases of spontaneous abortion,six cases of successful pregnancy,the overall pregnancy rate of 24%.TCM syndromes:0 cases cured,2 cases markedly effective in 14 cases,16 cases,the total efficiency of 56.25%.TCM symptoms total score decrease,P<0.05.5.after a course of high-dose treatment group operating frequency>4 uterine surgery patients endometrial thickness(7.68 ± 1.61)than before treatment(6.34 ± 1.59)increase,P<0.05.After treatment,the number of operations uterine surgery<4 patients with endometrial thickness(7.21 ± 1.74)than before treatment(5.20 ± 1.41)increase,P<0.05.6.after a course of high-dose treatment group uterine surgery ?4 times the number of operations at the blood flow in patients with endometrial RI(0.53 ± 0.06)than before treatment(0.74 ± 0.25)decreased,P<0.05.After treatment,the number of operations uterine surgery<4 times lower in patients with endometrial blood flow RI(0.63 ± 0.18)than before treatment(0.65 ± 0.17)decreased,P>0.05.7.After the first course of treatment,uterine surgery operation ?4 times and<4 times the two groups of patients before and after treatment of luteal phase E2(168.47 ±36.07,142.43 ± 59.11)(199.56 ± 75.82,239.20 ± 104.45),P(14.20 ± 4.91,15.04 ±5.87)(18.22 ± 7.29,18.38±5.57)comparison,P>0.05.8.32 cases of high-dose group,14 cases of patients taking two courses of treatment after two courses of endometrial thickness(7.76 ± 2.12mm)and a course of treatment(7.14 ± 1.54mm)than the increase was not obvious,P>0.05.conclusion1.Kangfuxin andremoving blood stasis and tonifying deficiency method can increase endometrial thickness in patients with thin endometrium.2.Kangfuxinandremoving blood stasisandtonifying deficiency method can reduce the arterial flow resistance under the endometrium,uterine blood flow to increase. |
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