Clinical Observation Of Colon Cleansing And Clearing Damp Granules In The Treatment Of Active Ulcerative Colitis (the Type Of Damp-heat Accumulation)

Objective: To observe the effect of Colon cleansing and Clearing damp Granules in the treatment of active Ulcerative Colitis(the type of damp-heat accumulation)and to explore new methods for the treatment of UC.Methods:A total of 87 patients were enrolled in this study,which were divided into the treatment group and the control group according to the random number table method.A total of 7 patients fell off and lost follow-up during the study,and finally 80 patients were included,40 in the treatment group and 40 in the control group.The treatment group was given orally Colon cleansing and Clearing damp Granules(Its compos ition includes,Rhizoma coptidis3g,Officinal Magnolia Bark3g,Herba Scut ellariae Barbatae15g,Oldenlandia diffusa30g,Polygonum Chinense10g,Radix Paeoniae Alba15g,Angelica Sinensis10g,Costustoot 6g,Areca catechu10 g,Rhizoma Atractylodis Macrocephalae10g,Angelica root10g,plantain herb15 g,Glycyrrhiza uralensis Fisch6g).Western medicine group was given mesalaqin entericcoated tablets 0.25g/ tablet,4 tablets at a time,and oral treatment 4 times a day.Patients in both groups were treated with a course of 4 weeks,and the drugs were discontinued after 2 courses of trea tment for review,followed up for 6 months.Blood routine,urine routin,stool routine,liver and kidney function and electronic colonoscopy were performed in the experiment and after the experiment.At the beginning and end of the experiment,the patients were evaluated by clinical sym ptom score,colonoscopy mucosa evaluation score,disease severity and activity evaluation,and quality of life score.Adverse reactions and sidee ffects were observed throughout the trial.The patients were followed up by telephone at the 6th months after the end of the experiment,and the difference in efficacy between qingchang huazhi granules and salaz in entericcoated tablets was compared,so as to evaluate the clinical efficacy of Colon cleansing and Clearing damp Granules in the treatment of active dampheatintrinsic Ulcerative Colitis.Results:(1)clinical symptom score: the clinical symptom score of both groups was decreased compared with that before treatment,and the diff erence was statistically significant(P<0.05),indicating that the treatment of both groups was effective;However,the clinical symptom scoreof the treatment group was lower,and the difference was statistically signifi cant(P<0.05)indicatingthe clinical effect of the treatment group was be tter than that of the control group,which could effectively improve the degree of abdominal pain,reduce the number of diarrhea,reduce purul ent blood and stool,and reduce the discomfort of tenescet et al in UC patients.(2)efficacy evaluation of TCM syndromes: after treatment,the total effective rate of TCM syndromes in the treatment group was 87.5%,higher than that in the control group(67.5%),and the difference was statistically significant(P<0.05).This indicates that the treatment gro up is superior to the control group in improving the curative effect of TCM syndromes.(3)mucosal evaluation score under colonoscopy: accor ding to Baron endoscopy scoring criteria,after two courses of treatment,Baron endoscopy scores of the two groups decreased compared with that before treatment,and the difference was statistically significant(P<0.05)indicating that the treatment was effective.However,there was no statis tically significant difference in Baron endoscopic score between the two groups after treatment(P>0.05)which may be caused by the fact that in flammatory factors have not been completely eliminated and intestinal mucosa has been stimulated by fecal residue for a long time,resulting in slow mucosal repair.(4)evaluation of disease severity and activity:after treatment,the Mayo scoring in both groups decreased compared with that before treatment,and the difference was significant(P<0.05),ind icating that the treatment was effective.However,the score in the treat ment group decreased by a greater extent,and the difference was statist ically significant compared with the control group(P<0.05),indicating that the clinical effect of the treatment group was better than that of the control group,which could effectively improve the degree of abdominal pain,reduce the number of diarrhea,reduce purulent bloodstool,and red uce the discomfort such as tenesmus in UC patients.(5)quality of life score: after treatment,both groups decreased compared with that before tr eatment,and the difference was statistically significant(P<0.05),indicating that the treatment was effective.However,compared with the control group,the improvement in the treatment group was significant,and the difference was statistically significant(P<0.05).It indicates that this prescription is superior to the control group in impr-oving the patients’ mood,happiness and quality of life.(6)safety:in the 2 courses of treatment,the incidence of adverse reactions was 2.5% in the treatment group and25% in the control group,and the difference between the two groups was statistically significant(P<0.05).In terms of safety,the treatment group was higher than the control group,with statistical significance(P<0.05).(7)comparison of serum CRP and ESR levels: after treatment,thelevels of CRP and ESR inflammatory factors in the two groups were significantly lower than before treatment,indicating that the treatment was effective.However,the decrease was more significant in the treatm entgroup at the same time,and the difference was significant(P<0.05),indicating that this prescription can reduce the inflammatory reaction of patients more than meisarazin entericcoated tablets.(8)comparison of recurrence rate: telephone follow-up 6 months after the end of treatment showed that The recurrence rate of the treatment group was lower than that of the control group,and the difference was statistically signific ant(P<0.05).It is suggested that this prescription has a lower recurrenc e rate in treating dampheat ulcerative colitis than meisarazin entericoate d tablets alone.Conclusion:Clinical observation of Colon cleansing and Clearing damp G ranules and mesalaqin entericcoated tablet have significant effects on im proving the degree of abdominal pain,diarrhea,purulent blood stool,ten escicius,TCM syndrome manifestations,endoscopic mucosal manifestations,disease severity and activity,as well as lowering the level of serum CRP and ESR,and improving the quality of life of patients with active damp-heat Ulcerative Colitis.In terms of safety and improvementof patients’ endoscopic mucosal performance,Colon cleansing and Clearing damp Granules has the same effect as mesalaqin enteri-coated tablet.The effect of Colon cleansing and Clearing damp Granules is betterthanmesal aqin enteric-coated tablets in improving patients’ clinical symptoms,TCM syndromes,disease severity and activity,lowering serum CRP and ESR levels,improving patients’ quality of life and reducing the recurrence rate.