Clinical Observation Of Traditional Chinese Medicine Combined With Laser In Treatment Of Ischemic Central Retinal Vein Occlusion

Object:To observe the clinical effect of traditional Chinese medicine of Xionggui huoxue decoction combined with laser in the treatment of ischemic central retinal venous occlusion.Method:A total of 78 patients(78 eyes)who met the diagnostic criteria for ischemic central retinal vein occlusion were assigned to a treatment group of 39 patients(39 eyes)and a control group of 39 eyes(39 eyes).The treatment group was given hospital agreement prescription:traditional Chinese medicine Xionggui huoxue decoction(day 1,bid,Oral),fundus laser(completed in 4,the time interval for 1 weeks)treatment;the control group was treated with laser photocoagulation(completed in 4,the time interval for 1 weeks)treatment.The course of observation was 12 weeks.A case-control study method to observe the two groups before and after treatment,the best corrected visual acuity,retinal hemorrhage area,fundus fluorescein angiography(FFA)optical coherence tomography retinal circulation time(OCT)and the posterior segment of the foveal thickness change.After 12 weeks,two groups of treatment effects were statistically analyzed.At the same time,ECG,blood routine,urine routine,blood biochemistry were examined before and after treatment,and the safety of the drugs was observed.Result:There was no statistical significance in the age,sex,time of onset and so on in 78 patients who met the inclusion criteria and entered the statistical analysis(P>0.05),and they were comparable.1.Comparison of the best corrected visual acuity between the two groups:the very effect of treatment group was 28.21%(11/39).effective 53.85%(21/39),the very effect of control group was 17.95%(7/39).effective 33.33%(13/39),the total effective(very effective+effective)rate of treatment group was 82.05%(32/39),the total effective(effective+effective)rate of control group was 51.28%(20/39),the difference between groups was 0.008(p<0.05),the difference was statistically significant.The results showed that the improvement of visual acuity was better in the treatment group than in the control group.2.Comparison of the area of retinal hemorrhage in the two groups:before treatment,the patients in the two groups had a wide range of bleeding,bleeding area 10-20PD,>20PD,respectively,treatment group were 53.85%(21/39),46.15%(18/39),control group were 58.97%(23/39),41.03%(16/39),group comparison p=0.353,no statistically significant,comparable.After 12 weeks,bleeding area ?10PD,10-20PD,>20PD,respectively,the treatment group was 41.03%(16/39),43.59%(17/39),15.38%(6/39),control group was 28.20%(11/39),41.03%(16/39),30.77%(12/39),compared with the treatment before treatment,p<0.001 and p=0.032,respectively.There was no statistically significant between group and group p=0.156.After 12 weeks,the very effective of treatment group showed 41.03%(16/39),effective 43.59%(17/39),the very effective of control group was 28.20%(11/39),effective 35.90%(14/39),the total effective rate of treatment group was 84.62%(33/39),the total effective(very effective+effective)rate was 64.10%(25/39),the difference between group p=0.027(p<0.05),the difference was statistically significant.The results showed that the area of retinal hemorrhage in the treatment group was better than that in the control group.3.Two groups of patients with FFA examination results comparison:before treatment.the two groups of patients with retinal circulation time group P=0.585,no statistical significance,comparable.After 12 weeks of treatment,the two groups of retinal circulation time were better than before treatment,compared with P=0.014 in the treatment group and P=0.027 in the control group,there was a statistically significant difference between the two groups,P=0.725 was not statistically significant.4.Comparison of concave thickness of macular center in the two groups:The treatment group and the control group of the control group were respectively 481.51±133.24um?452.67±136.62um,after treatment were respectively 304(194)um?342(215)um.Group comparison:treatment group P=0.196.control group P=0.265.no statistical difference was found in both groups.After treatment,the very effective of treatment group showed 7.69%(3/39).effective 35.90%(14/39),the very effective of control group was 2.56%(1/39).effective 28.21%(11/39),the total effective(very effective+effective)rate of treatment group was 43.59%(17/39),the total effective(very effective+effective)rate of control group was 30.77%(12/39),the difference between group p=0.879(p>0.05),the difference was not statistically significant.5.Two groups of patients before and after treatment ECG,blood routine,urine routine,blood biochemical tests were not obvious abnormalities,the treatment period found no complications caused by treatment and adverse reactions.Conclusion:1.Xionggui huoxue decoction combined with laser treatment of ischemic central retinal vein occlusion can effectively improve the visual acuity,promote retinal hemorrhage absorption and improve retinal microcirculation.2.Xionggui huoxue decoction combined with laser treatment of ischemic central retinal vein occlusion in the improvement of macular edema,the treatment group showed no significant advantage over the control group.3.Any adverse reactions and adverse events did not occur during the period of taking Xionggui huoxue decoction,it is safe and effective.