Study On Risk Factors Of Gastroesophageal Reflux Disease In Population

Objectives:So far,Shandong Province still lacks a large-scale investigation of gastroesophageal reflux disease?GERD?,and the incidence and risk factors of the disease are still unclear.This article intends to further explore the prevalence and risk factors of GERD in Shandong,provide reference for the prevention and treatment of GERD,and explore the possible risk factors for men and women,and identify the next GERD related research areas.Oral flora plays an important role in the occurrence of many diseases.It has been reported that oral flora is associated with periodontitis and rickets,but there is still a lack of reports on the relationship between GERD and oral flora.Methods and materials:A cohort study was conducted on the natural population of 18 years old and above who was field surveyed in Shandong from 2017.11 to 2018.04.The GerdQ scale was used as the basis for GERD diagnosis.The total score was 8 points or more as the case group,and the other 8 points or less.The study subjects were the control group.Questionnaires were used to collect age,gender,marital status,education level,work intensity,physical activity,lifestyle,diet,sleep status,snoring,sleep duration,hypertension,diabetes,coronary heart disease,hyperlipidemia and other accompanying disease history.The risk factors associated with GERD in the study population were significantly different due to the prevalence of males and females.Gender was used as a stratification basis to study the risk factors associated with GERD in men and women.Univariate analysis of relevant factors was performed to determine the possible risk factors for GERD.Then,the P<0.1 variable was included in the multivariate logistic regression analysis,and the stepwise regression method was used to determine the independent risk factors of GERD.In order to explore the correlation between GERD and oral flora,20 saliva samples were randomly selected from GERD and non-GERD to identify the oral flora changes in patients with gastroesophageal reflux disease.Provide reference for the diagnosis and treatment of GERD.Results:1.The incidence of GERDThere were a total of 5,334 questionnaires of which 5,149 were included in the analysis.According to the GerdQ scoring system,8 points were divided into nodes.A total of 570 respondents were diagnosed with GERD.The population incidence rate was 11.1%.A total of 214 males were diagnosed as GERD.The incidence of GERD was 8.4%,and 356 of the women were diagnosed with GERD,and the incidence rate was 13.7%.There was a statistically significant difference between men and women?P<0.001?.2.Risk factors associated with GERD in the populationCompared with men,the risk of female GERD increases,and the risk of GERX)increases with age.Hyperlipidemia,difficulty falling asleep,and snoring are associated with the onset of GERD.Investigators who ate spicy every day were less likely to be sick than those who did not eat spicy,and for those who occasionally ate spicy,this correlation was not found.Drinking tea may be a protective factor.3.Relevant risk factors for different gender groups:3.1 Multivariate logistic regression analysis showed that smoking increased the risk of GERD in male patients.The risk of GERD increases with age,and the risk of disease is increased by 4.32 times in people over 60 years of age.3.2 Multivariate logistic regression analysis of risk factors associated with female patients,age is an independent risk factor for GERD.Insufficient sleep time increases the risk of GERD.Difficulty falling asleep increases the incidence of GERD.Frequent sleep and snoring will significantly increase the incidence of GERD,and they are positively correlated.Hyperlipidemia can aggravate the occurrence of GERD and is an independent risk factor for GERD,which can increase the prevalence by 3.71 times.Eating spicy foods every day or almost every day may be a protective factor for GERD.4.GERD patients with oral flora changes4.1.A total of 17 genus of bacteria were found at the level of the oral saliva group in patients with GERD and the control group.There was no significant difference in the composition of the two groups of samples.Bacteroide,Proteobacteria,Firmicutes,Fusobacteria,Actinobacteria,and Saccharibacteria account for 95%of the oral flora,the above.The ratio of GERD to the control group was different.Compared with normal,the Bacteroides and Proteobacteria of GERD patients increased,but the thick-walled and Clostridium gates decreased.4.2.The dominant flora of oral sputum flora in GERD patients and control subjects is Neisseria,Veillonella,Prevotella₇,Porphyromonas,Prevotella,Streptococcus,Haemophilus,Fusobacterium,Capnocytophaga,accounting for 92%the above.The species composition of the two species is basically similar,but compared with GERD,the Neisseria of the control group is relatively increased.4.3.Compared with the control group,the species richness and diversity of the GERD community decreased.But there is no statistically significant difference between them.Conclusion:1.For the population,women,age,hyperlipidemia,difficulty falling asleep,snoring may be independent risk factor for GERD.In addition,drinking tea or spicy diet may be protective factors for GERD.2.In male patients,age,smoking and work intensity are independent risk factors for GERD.3.Among female patients,age,sleep time shortening,difficulty falling asleep,snoring,and hyperlipidemia are independent risk factors for GERD.Spicy diet may be protective factor for GERD.Different risk factors for GERD in different sexes can be taken differently to prevent the occurrence of GERD,which provides further reference for treatment.4.There is no significant change in the abundance and diversity of oral flora in GERD patients.4.1.The composition of salivary flora in the GERD group and the control group was basically the same at the level of the portal and genus,and there was no significant difference in relative abundance.4.2.Compared with the control group,the GERD group had no statistical difference in species richness and community diversity.