Study On The Correlation Between Intestinal Barrier Function And Neurological Deficit And Short-term Prognosis In Patients With Ischemic Stroke

Objective:The levels of diamine oxidase(DAO)and D-lactate(D-LAC)in serum are reliable indicators reflecting intestinal barrier function.This research explored whether intestinal barrier function is impaired in patients with ischemic stroke and the relationship between intestinal barrier function and neurological impairment and short-term prognosis in patients with ischemic stroke.Methods:A total of 130 patients with ischemic stroke in the department of Neurology of Baoding NO.1 Central Hospital from Dec.1,2017 to July 1,2018 were selected as stroke group and 52 healthy persons as control group.The levels of DAO and D-LAC in serum of the two groups were determined by enzyme-linked immunosorbent assay(ELISA).SPSS19.0 statistical software was used to analyze the experimental data.NIHSS score was used to assess the degree of neurological deficit in the stroke group at admission.Two independent samples t test was used to analyze the impairment of intestinal barrier function in patients with ischemic stroke.Pearson related factors were used to analyze the relationship between intestinal barrier function and the degree of neurological deficit in patients with ischemic stroke.The patients with ischemic stroke were divided into good prognosis group(0-2 points)and poor prognosis group(more than 2 points).Multivariate logistic regression was used to analyze the relationship between serum DAO and D-LAC levels and short-term prognosis of patients with acute ischemic stroke.The difference was statistically significant when P< 0.05.Results:1 The levels of DAO and D-LAC in the stroke group were significantly higher than those in the control group(P < 0.05),and the difference was statistically significant(Table 1).2 There is a positive correlation between intestinal barrier dysfunction and the degree of neurological deficit in patients with ischemic stroke.3 The levels of serum DAO and D-LAC in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P < 0.05)(Table 2).Multivariate logistic regression analysis showed that the elevated levels of serum DAO(OR 1.672,95%CI(1.038~2.691),P 0.034)and D-LAC(OR 1.339,95%CI(1.007~1.781),P 0.045)were independent risk factors affecting the prognosis of acute ischemic stroke after checking age,sex,hypertension,baseline systolic blood pressure,blood sugar and other factors(Table 3).Conclusion:1.Intestinal barrier function is impaired in patients with ischemic stroke.2.The intestinal barrier function may be positively correlated with the degree of neurological deficit in patients with ischemic stroke.3.Impaired intestinal barrier function in patients with ischemic stroke may have adverse effects on their short-term prognosis.