| Objective:Through clinical randomized controlled trials,systematic observation of Mongolian medicine combined with koumiss for the treatment of Ulcerative colitis(UC),and the UC-induced diarrhea,pus and bloody stools,abdominal pain,bloating,tenesmus,bowel,loss of appetite and other major symptoms and signs,and provide the theoretical basis for the study of Mongolian medicine combined with koumiss for the treatment of Ulcerative colitis.Method: The patients were enrolled in the International Mongolian Medicine Hospital of Inner Mongolia Autonomous Region,the First Affiliated Hospital of Inner Mongolia Medical University from 2017.10-2019.2.The modified Mayo scoring system was diagnosed as mild-moderate patients,and 75 patients met the diagnostic criteria of Mongolian medicine.The 75 patients who met the diagnostic criteria and inclusion criteria of ulcerative colitis(UC)were randomly divided into observation group,control group I and control group II.The observation group received oral administration of Aolegai-13,Aoyou-13,Hailumule-9,Bateer-7 and other Mongolian medicine,and was treated with oral koumiss.The control group I was treated with oral Mongolian medicine,and the drug type was the same as that of the observation group.In the control group II,oral Salofalk enter-coated tablets were administered orally in four weeks,and all three groups were treated for one course of treatment.The symptoms,signs and stool routine examinations of the three groups were scored and compared before and after treatment.Results:1.Comparison of clinical total effective rates:The patients in the observation group were the total effective rate was 72.22%.In the control group I the total effective rate was 60%.The control group II the total effective rate was 74.07%.There were differences between the three groups,which were statistically significant.(P< 0.05).2.Comparison of the total effective rate of symptoms:The patients in the observation group were the total effective rate was 88.89%.The control group I patients were the total effective rate was 66.67%.The control group II patients were the total effective rate was 81.84%.There was a difference between the observation group and the control group I,which was statistically significant(P< 0.05),There was no difference between the observation group and the control group II,which was no statistical significance.(P> 0.05).3.Comparison of symptoms before and after treatment:⑴ After treatment,the patients in the observation group had obvious differences in diarrhea,pus and bloody stools,abdominal pain,tenesmus,bowel sounds and loss of appetite.the difference was statistically significant.(P< 0.05)Control group I had differences in diarrhea,pus and bloody stools,abdominal pain,bloating,tenesmus and loss of appetite,the difference was statistically significant(P< 0.05),however,there was no difference in bowel sounds,no statistical significance.(P> 0.05)Control group II had differences in diarrhea,pus and bloody stools,abdominal pain,bloating,tenesmus,and statistical significance(P< 0.05),however,there were differences in bowel sounds and loss of appetite,and the difference was not statistically significant.(P> 0.05).⑶ The symptoms of the three groups of patients were compared between the groups after treatment.For the symptoms of bowel sounds,the observation group was better than the control group I,which was statistically significant(P< 0.05),there was no significant difference between the observation group and the group II(P>0.05).There was a difference between the two control groups,which was statistically significant(P<0.05).The symptoms of loss of appetite were significantly different between the observation group and the control group II,(P<0.05)but there was no difference between the observation group and the group I,and there was no statistical significance(P>0.05).There was a difference between the two control groups,which was statistically significant(P<0.05).There were no differences in symptoms such as diarrhea,pus and bloody stool,abdominal pain,abdominal distension,and tenesmus in the three groups.The difference was not statistically significant(P> 0.05).4.The comparison of symptoms before and after treatment : there were differences in the three groups,the difference was statistically significant(P<0.05),there were no differences between the groups in the three groups,and the difference was not statistically significant(P>0.05).5.There were no differences in the RBC comparison between the three groups after treatment: there was no significant difference(P>0.05).6.Comparison of drug safety: No significant side effects were observed and controlled group I.Control group II two patients showed nausea,dizziness and other adverse reactions.There was no difference between the three groups and there was no statistical significance(P > 0.05).Conclusion :Mongolian medicine combined with koumiss treatment has a significant effect on mild and moderate UC in active period.Especially for the improvement of the main symptoms caused by UC like diarrhea,pus and bloody stools,abdominal pain,bloating,and tenesmus.The therapy has the characteristics and advantages of being safe,effective,and having little side effects.It is worthy of widespread application in clinical practice. |
