Distribution Characteristics Of Traditional Chinese Medicine Syndromes In Adult Patients Of OSAHS With MCI

ObjectivesThrough cluster analysis and artificial interpretation,to explore the characteristics of Traditional Chinese Medicine?TCM?syndromes in adults patients of obstructive sleep apnea hypopnea syndrome?OSAHS?with mild cognitive impairment?MCI?were analyzed,and analysis of the relationship between different indicators of TCM syndromes,to provide some theoretical reference for TCM syndrome differentiation and curative effect judgment of OSAHS patients with MCI.MethodsFrom February 2018 to December 2018,134 patients of OSAHS with MCI who met the case inclusion criteria were collected in from the Respiratory Department of The second people's Hospital affiliated to Fujian University of traditional Chinese Medicine.These pati-ents General data?such as sex,age,height,weight,current residence,occupation,years of education?were recorded,ESS,MoCA scores were performed,and AHI,LSaO₂,TSP90%data were obtained by polysomnography.The symptoms were collected by the self-made information collection form of four diagnostic methods of TCM.TCM syndromes were obtained through cluster analysis and artificial interpretation,and relevant statistical analysis was performed using Statistical Product and Service Solutions 20.0.?P<0.05,the difference was statistically significant?Results1.Distribution of information on four diagnostics of Chinese medicine:The main symptoms and signs of 134 subjects included in this study were night snoring,forgetfulness,lethargy,physical obesity,thirst,intelligent decline.The main tongue is a reddish tongue and white greasy tongue coating.The main pulse is moist,slow,and slide.2.The results of cluster analysis:obtained 6 types of TCM syndromes.That is,The distribution of syndromes was 41 cases?31.78%?of phlegm-dampness syndromes,32cases?24.81%?of phlegm heat syndromes,25 cases?19.38%?of phlegm and blood stasis syndromes,20 cases?15.50%?of spleen-kidney deficiency syndromes,7cases?5.43%?of lung and spleen qi deficiency syndromes,4 cases?3.10%?of heart and liver qi deficiency and blood stasis syndromes.In addition,the TCM syndrome differentiation of 5 patients does not belong to the TCM syndrome type mentioned above.The cases of lung and spleen qi deficiency syndrome and the heart-liver qi deficiency and blood stasis syndrome are fewer,so there were no further data study was carried out.3.Comparison of the related indexes of different TCM syndrome types:There was no significant difference in sex,current residence,occupation,years ofeducation,attention,nomenclature among the four types of patients with phlegm-dampness syndromes,phlegm heat syndromes,phlegm and blood stasis syndromes,spleen-kidney deficiency syndromes?P>0.05?.The BMI,AHI,ESS score of phlegm-dampness syndromes was lower than that of other syndrome types.The LSaO₂,MoCA score and the gift of tonguesl,visual space and executive ability of phlegm-dampness syndromes were higher than those of other syndrome types?P<0.05?.The AHI,ESS score,TSP90%of spleen-kidney deficiency syndromes was higher than that of other syndrome types,and the MoCA score,orientationability level of spleen-kidney deficiency type was lower than that of other syndrome types?P<0.05?.4.Correlation analysis between AHI,MoCA score and related indexes of different TCM syndrome types:The AHI of phlegm-dampness syndromes was negatively correlated with LSaO₂?r=-0.57,P<0.05?,and the ESS score of phlegm-dampness syndromes was positively correlated?r=0.67,P<0.05?.The MoCA score of phlegm-dampness syndromes was negatively correlated with ESS score?r=-0.35,P<0.05?;The AHI of the phlegm heat syndromes was negatively correlated with LSaO₂?r=-0.40,P<0.05?,and positively correlated with the TSP90%and ESS scores?r=0.65,P<0.05 and r=0.50,P<0.05?,and its score of MoCA was negatively correlated with the ESS score?r=-0.47,P<0.05?;The AHI of thephlegm and blood stasis syndromes was positively correlated with the ESS score?r=0.57,P<0.05?,and the AHI of the spleen-kidney deficiency syndromes was positively correlated with the TSP90%?r=0.48,P<0.05?.Conclusions1.The main TCM syndrome types of adult patients with OSAHS merge MCI can be divided into phlegm-dampness syndromes,phlegm heat syndromes,phlegm and blood stasis syndromes,spleen-kidney deficiency syndromes,lung and spleen qi deficiency syndromes,heart and liver qi deficiency and blood stasis syndromes,and the phlegm-dampness syndromes is the main type.2.In adult patients with OSAHS and MCI,the degree of cognitive function damage was relatively mild in patients with phlegm-dampness internal obstruction type,and relatively serious in patients with spleen-kidney deficiency type.3.The ESS score can be used to predict the AHI level of the adult patients of OSAHS with MCI who belong to phlegm-dampness syndromes,phlegm heat syndromes,phlegm and blood stasis syndromes.And ESS score can predict the severity of cognitive impairment in patients of OSAHS with MCI who's belong to phlegm-dampness syndromes,phlegm heat syndromes.