Relationship Between Urinary Iodine Distribution And Thyroid Function Status Of Tibetan Adults In Lhasa

Background Lhasa is located in China’s high-cold and high-altitude areas,and its sanitary conditions are relatively backward.There are few reports on the iodine nutritional status of Tibetan people in the plateau.In this study,the status of current iodine nutrition in Tibetan adults in Lhasa was evaluated by urinary iodine levels,goiter rate and thyroid function.Methods Though multi-stage stratified cluster random sampling of Tibetan adults in Lhasa Urban and surrounding rural areas,urine and serum were collected to measure urinary iodine concentration(UIC)and thyroid function(Including thyroid stimulating hormone,TSH,thyroid peroxidase antibody,TPOAb,thyroglobulin antibody,TGAb.when TSH exceeds normal value,increase measurement free thyroxine,FT4.when TSH is less than normal value,increase measurement FT4 and free triiodothyronine,FT3.),and thyroid size was examined by color ultrasound.Results A total of 2,295 Tibetan adult subjects,2,160 had UIC,thyroid function(among them 492 had FT4 examinations,and 22 had FT3 examinations)and thyroid ultrasound examinations The study concluded that: Urine iodine showed a skewed distribution,with a median(upper and lower quartiles)indicating 154(99;229)leve The insufficient iodine intake group was 25.6%,the appropriate group was42.0%,the more than adequate group was 20.8%,and the excessive group was 11.6%.There was no difference between male and female(P>0.05),and the urban was higher than rural(P<0.05).Urine iodine decreased with age(P<0.05).The prevalence of goiter was 4.7%,and female higher than male(P<0.05).There was no difference between urban and rural areas(P>0.05),and the prevalence rate increased with age(P<0.05).All thyroid functions are within the normal range.With the increase of urinary iodine concentration the prevalence of TPOAb positive decreased gradually(P<0.05).Conclusion The status of current iodine nutrition of Tibetan adults in Lhasa is not optimistic.There are still more than 50% of people with low iodine or high iodine,and the prevalence of goiter is high.Thyroid function is at normal level,but there is no clear relationship with urinary iodine.In the future,it is necessary to strengthen the monitoring of iodine nutrition status of residents in Lhasa and adopt different intervention measures for low iodine and high iodine areas.