| Objective:To observe the comparison from liver benefit stomach decoction combined pantoprazole sodium enteric-coated capsules treating liver stomach with chronic erosive gastritis debaucjed of the improvement of clinical symptoms,endoscopic repair effect,HP infection rate,recurrence rate and safety indicators such as indicators of comparative study,objective evaluation from liver benefit stomach decoction combined pantoprazole sodium enteric-coated capsules in the treatment of liver stomach with chronic erosive gastritis curative effect and application prospect.Methods:A total of 60 cases were selected from the outpatient and ward of the department of hepatobiliary spleen and stomach of wuhan hospital of traditional Chinese medicine from May 2018 to May 2019,which all met the diagnostic criteria of chronic erosive gastritis in western medicine and the diagnosis of dialectical liver-stomach disharmony in traditional Chinese medicine.According to the inclusion and exclusion criteria of the subjects,the patients were divided into the treatment group and the control group by random number table method according to the order of visit,with 30 patients in each group.After statistical test,there was no significant difference in age,gender and other indicators,which was comparable.In the control group,pantoprazole sodium enteric capsule(pantoprazole 20mg)was taken twice a day with warm water half an hour before breakfast and dinner.The treatment group was treated with self-designed shugan yiwei decoction combined with pantoprazole sodium enteric capsule,and the western medicine was taken in the same way as the control group.The Chinese medicine decoction was taken in 2 bags daily,and one bag was taken in half an hour after breakfast and dinner,about 200 mL.After 6 weeks of treatment,the clinical syndrome score,endoscopic erosion repair effect,HP infection rate and total clinical efficacy of the two groups were compared before and after treatment,and the difference was tested by statistical methods.A follow-up survey was conducted 12 weeks after the end of treatment to calculate the recurrence rate and evaluate the prognosis of the two treatments.Results:(1)On the improvement of clinical syndrome score,the TCM syndrome score of the two groups decreased significantly after treatment compared with before treatment P < 0.01,showing a significant statistical difference.After treatment,P <0.05 was obtained between the two groups,and the treatment group was significantly better than the control group in terms of symptom improvement(2)In terms of the degree of erosion repair of gastric mucosa,statistical examination of the degree of erosion repair of patients in the two groups showed that was P>0.05,showing no significant difference.The effective rate of the treatment group was 96.67%.The effective rate of the control group was 86.67%,and the erosion repair rate of the treatment group was higher than that of the control group.(3)After treatment,the infection rate of HP in the two groups was statistically tested at P >0.05,with no significant statistical difference.However,the negative conversion rate of HP in the treatment group(30.43%)was better than that in the control group(4.76%).(4)The total effective rate of the treatment group was 96.67%,and the cure rate was 60.00%.The total effective rate of the control group was 83.33%,and the cure rate was 23.33%.The clinical total effective rate of the two groups was statistically different(P < 0.05),and the total effective rate of the treatment group was better than that of the control group.(5)The patients in the two groups were followed up after 12 weeks,and the degree of recurrence of the patients in the two groups was statistically tested P <0.05,indicating that the treatment group was significantly better than the control group in terms of disease prognosis.Conclusion:Self-designed shugan yiwei decoction combined with pantoprazole sodium enteric capsule significantly improved the clinical symptoms of patients with chronic erosive gastritis.Compared with patients who only used pantoprazole sodium enteric capsule,the efficacy was better,and the long-term recurrence rate was better in the combination group,which is worthy of further research and clinical use. |
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