| Objective: By observing the correlation between the syndrome type of uyghur Medicine with thyroid function and sex hormones in Hyperplasia of mammary gland(HMG),explore the inner connection between them,clarify its pathogenesis,provide scientific basis for HMG's syndrome differentiation and diagnosis and treatment.Methods: This subject used clinical research methods,212 cases were collected according to Western and uyghur medicine diagnostic criteria of HMG patients,and classified the syndrome type differentiation based on the criteria of abnormal body fluid classification in uyghur medicine.The general data,thyroid function indexes,and Sex hormone index were recorded and analyzed the relationship between each index and the HMG syndrome type in uyghur medicine through statistical test.Results:1)The results of the uyghur medicine syndrome type of HMG patients in this study were: 95 cases(44.81%)of astringent balgham type,88 cases(41.51%)of increasing sawda type,and 29 cases(13.68%)of leek color sepra type.The frequency of occurence: astringent balgham type > increasing sawda type > leek color sepra type;2)There was significant difference between the ages and the uyghur medicine syndrome type of HMG patients(P < 0.05).the most patients were in the age of 36-45,the age of 36-45 was the high incidence age of HMG,and the most of them was in astringent balgham type.3)There was significant difference in BMI between the uyghur medicine syndrome types of HMG patients(P <0.01),and the astringent balgham type was the most significant.4)There was no significant difference in the mean level of thyroid function related indexes(T3,T4,FT3,FT4,TSH,anti TG,anti TPO)among HMG patients with different uyghur medicine syndrome types(P > 0.05).the highest proportion was astringent balgham type.5)The multi-factor analysis of the influencing factors of T4 showed significant differences in age and solid nodules(P <0.05),that is,the older the age of HMG patients,the lower the serum T4 level(?=-0.376,P=0.038),combined with solid thyroid nodules Of HMG patients had higher T4 levels than those with normal thyroid B-ultrasound results(?=0.769,P=0.033).6)The multi-factor analysis of the influencing factors of FT4 showed that the differences among the uyghur medicine syndrome types were statistically significant(P <0.05),the FT4 level of increasing sawda type of HMG patients was lower than astringent balgham type of HMG patients(?=-1.176,P=0.019);7)The multi-factor analysis of the influencing factors of TSH showed that the difference of diffuse nodules was statistically significant(P <0.05),the HMG patients with diffuse thyroid nodules had higher TSH levels than those with normal thyroid B ultrasound results(?=2.419,P=0.000);8)The multi-factor analysis results of Anti-TG and Anti-TPO influencing factors showed that the difference between diffuse nodules and hypoechoic nodules was statistically significant(P <0.05),HMG patients with diffuse nodules and hypoechoic nodules Anti-TG and Anti-TPO levels are higher than those with normal thyroid B-ultrasound results;9)There was a significant difference in thyroid nodule between the uyghur medicine syndrome types of HMG patients(P < 0.01),that is,111 of 212 HMG patients detected thyroid nodule,and the astringent balgham type has higher frequency.10)There was no significant difference in the average level of sexual hormone indexes(FSH,E2,LH,PRL,PRG,T)between different uygur medicine syndrome types of HMG patients(P > 0.05).The level of FSH,E2,PRL,T was increased in patients with abnormal sexual hormone level,and the level of LH and PRG was decreased,among which astringent balgham type accounted for the highest proportion;11)the multi factor analysis results of FSH influencing factors showed that there was a uniform age difference Statistical significance(P < 0.05),that is,the older HMG patients were,the higher FSH level was(?=10.956,P=0.000);12)The results of multi-factor analysis of the influencing factors of LH showed that the difference of hypoechoic nodules was statistically significant(P <0.05),patients with HMG with hypoechoic thyroid nodules had higher LH levels than patients with normal thyroid B-ultrasound results(?=32.712,P=0.008);13)The multi-factor analysis of PRG influencing factors shows that the age is statistically significant(P <0.05),the older the HMG patients,the lower the serum PRG level(?=-2.386,P=0.025);14)The multi-factor analysis of the influencing factors of T showed statistically significant differences in age and cystic nodules(P <0.05),the older the age of HMG patients,the lower the T level(?=-5.389,P=0.020),combined with cystic thyroid The T levels of HMG patients in this section were lower than those of HMG patients with normal thyroid B-ultrasound results(?=-8.439,P=0.012).Conclusion: 1)The main Uyghur medicine syndrome type of HMG is astringent balgham type.2)In patients with HMG,abnormal thyroid function-related indicators are most commonly seen with elevated levels of TSH,Anti-TG and Anti-TPO,increasing sawda type accounts for the highest proportion,and it can be considered that increasing sawda type HMG patients are more prone to thyroid dysfunction.3)In patients with HMG,the abnormal sex hormone index is increased by FSH,PRL,T,E2,and the decrease of LH and PRG is the most common,astringent balgham type accounts for the highest proportion,It can be considered that astringent balgham type HMG patients are more likely to have sex hormone disorders. |
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