Changes Of Choroid Thickness In Patients With Diabetic Retinopathy And Analysis Of Factors Related To Choroid Thickness

Objective:Observe the changes of choroid thickness in patients with diabetic retinopathy at different stages;and analyze the relevant factors of changes in choroid thickness,so as to provide corresponding reference for the goal of disease control in patients with diabetes.Methods:This study used a prospective,non-randomized controlled met hod.Patients who underwent fundus examination at the ophthalmology clinic of the First Affiliated Hospital of Hunan Normal University were diagnosed as type 2 diabetes by endocrinologists from September 2019 to December 2019.136 patients(266 eyes)were divided into three groups A,B,and C according to the staging criteria for diabetic retinopathy.Group A:no obvious retinopathy,group B:non-proliferative diabetic retinopathy,and group C:proliferative diabetic retinopathy..A total of 16 patients(22 eyes)of non-diabetic patients of the same age group were the normal control group.All patients underwent visual acuity,intraocular pressure,fundus photo,slit lamp,optical coherence tomography,comparison of retinal thickness and choroid thickness between different groups and different positions,and collected the course,age and serum glucose,Correlation analysis of test data such as glycated hemoglobin,fructosamine,urine microalbumin,urine creatinine,urine microalbumin/urinary creatinine and choroid thickness.Results:1.There was no significant difference in gender,age and intraocular pressure between different groups(P>0.05);2.The thickness of the foveal retina between different groups was stat istically significant(P <0.05),group B was higher than group A,group C was higher than the other three groups;the upper retinal thickness between different groups was statistically significant(P <0.05),Group B and C were higher than group A and normal group;the lower retinal thickness was statistically different between different groups(P <0.05),group B was higher than normal group,group C was higher th an group A and normal group;nose between different groups The lateral retinal thickness was statistically significant(P <0.05).Group B was higher than group A and normal group,group C was higher than the other three groups;the temporal retinal thickness between different groups was statistically significant(P <0.05),Group C is higher than group A,the normal group is significantly lower than the other three groups;3.The difference in choroidal thickness(P <0.05)and lower(P <0.05)between the different groups was statistically significant,and the normal group was significantly lower than the other three groups;0.05),the A and B groups were higher than the normal group;the difference in nasal choroid thickness between the different groups was statistically significant(P <0.05).4.There was no correlation between gender and centroid choroid thickness(t=-0.343,P=0.732);glycated hemoglobin was positively correlated with centroid choroid thickness(r=0.484,P<0.05),disease course,serum glucose,fructosamine,There was no correlation between urinary microalbumin,urinary creatinine,urinary microalbumin/urinary creatinine,and central choroid thickness.Conclusion1.Diabetes can cause increased choroidal thickness;2.There is a positive correlation between the glycated hemoglobin and the thickness of the foveal choroid;3.Optical coherence tomography can achieve accurate measurement of retina and choroid thickness.