The Feasibility Of Cord Blood Autotransfusion In The Operation Of Labor And Neonate

Background: With the continuous improvement of prenatal screening and prenatal diagnosis techniques and the types and complexity of neonatal surgical operations,surgical procedures for the diagnosis of neonatal birth defects and neonatal operations are very important means of treatment.Neonatal transfusion plays an important role in the rescue and treatment of some neonatal diseases.Objective To investigate the feasibility of the application of autologous umbilical cord blood transfusion in intrapartum neonatal surgery.Methods From August 2008 to December 2018,15 cases of birth defects diagnosed in Shengjing Hospital affiliated to China Medical University who had received prenatal or neonatal surgery and had cord blood retained for autologous transfusion were selected.Routine biochemical tests were performed on the retained cord blood and the peripheral blood of the children before transfusion,follow-up was conducted on the postoperative infants with autologous blood transfusion,and blood routine tests and other relevant postoperative indicators,such as length of hospital stay and duration of intravenous nutrition support,were tested.Results Comparing the routine blood test of umbilical cord blood of the fetuses with that of the peripheral blood of neonates,there was no obvious statistical difference in the number of red cells[(4.15 ± 0.35)× 1012/L,(4.39 ± 0.31)× 1012/L,P=0.069],erythrocyte deposited[0.4749±0.047,0.5072±0.0367,P=0.052],the number of hemoglobin[(156.67±13.28)g/L,(166.47±13.73)g/L,P=0.065]or platelet count[(226.13 ± 39.84)× 1012/L,(211.40 ± 49.22)× 1012/L,P=0.391].No adverse reactions were observed after umbilical cord blood transfusion.After transfusion,hemoglobin reached the predetermined indexes,and no second transfusion was performed.Conclusion The index of autologous umbilical cord blood is basically the same as that of neonatal peripheral blood,and it is simple,easy and cheap,which avoids the adverse reaction of allogeneic adult blood transfusion;there was no adverse prognosis.Therefore,it can be used for neonatal blood transfusion preparation..