Meta-analysis On The Promotion Of Wound Healing By Regulating MicroRNA

Objective To systematically evaluate the effect of regulating micro RNA on wound healing.Methods There were 7 databases searched with subject words and free words: Pub Med,The Cochrane Library,EMbase,CNKI,Wanfang,VIP,CBM.The two reviewers screened all literatures that were retrieved through databases by referring to the pre-set inclusion and exclusion criteria,extracted data from the final included RCTs,conducted quality evaluation through the Cochrane Collaboration's tool for assessing risk of bias,and performed meta-analysis with Rev Man 5.3.Result Finally,10 Randomized controlled trials conforming to inclusion and exclusion criteria were included,with a total sample size of 186 cases.Meta-analysis showed that compared with the negative control group,the wound of regulating mi R healed faster on days 7,10 and 14(day 7: SMD=3.04,95%ci =[1.26,4.83],P=0.0008)(day 10: SMD=3.12,95%ci =[1.34,4.90],P=0.0006)(day 14: SMD = 3.08,95% CI = [1.16,5.00],P = 0.002),raise less the neutrophils(SMD = 3.15,95% CI = [5.04,1.26],P = 0.001),and produce more new vessels(SMD = 3.34,95% CI = [2.40,4.27],P < 0.00001).Conclusion By regulating the expression of mi R,it can promote the generation of wound neovascularization,reduce local inflammatory response and speed up the process of wound healing.However,more RCTs with a large sample size are still needed to prove this option in the future.