The Clinical Study On The Treatment Of Kidney-nourishing And Blood-activating Decoction On Hypomenorrhea With Kidney Deficiency Syndrome

Objective:Kidney-nourishing and Blood-activating Decoction is the prescription of director Zhang Jing's experience in the treatment of Hypomenorrhea with Kidney Deficiency Syndrome.The purpose of this study is to evaluate the clinical efficacy of Kidney-nourishing and Blood-activating Decoction in the treatment of Hypomenorrhea with Kidney Deficiency Syndrome,further explore the mechanism of its action in the treatment.Methods:A total case of 80 patients who were admitted to the gynecological outpatient department of First Teaching Hospital of Tianjin University of TCM from October 2018 to December2019 and met the inclusion and exclusion criteria were randomly divided into the treatment group and the control group according to the random number table method.There were 40patients in each group,and 5 patients were eliminated from each group by the end of the treatment.The treatment group received the treatment of Kidney-nourishing and Blood-activating Decoction,and the control group received Jiajian Guishen Pill came from Jing yue's complete work.At the end of treatment,we observe the changes of the relevant efficacy indicators of the two groups.Results:1.Comparison of menstrual volume:After treatment,the chart scores of menstrual blood loss map in the observation group and the control group increased compared with that before treatment,and the difference were statistically significant?P<0.01?.The time points were compared between the two groups,and there was no statistically significant difference in the chart score of menstrual blood loss between the two groups after 1 menstrual cycle?P>0.05?.There were statistically significant differences in the chart score of menstrual blood loss between the two groups after 2menstrual cycles and 3 menstrual cycles?P<0.05?.2.Comparison of endometrial thickness in mid-luteal phase:The endometrial thickness in mid-luteal phase in the two groups increased after treatment compared with before,and the differences were statistically significant?P<0.01?.The comparison between the two groups after treatment showed no statistically significant difference?P=0.05?.3.Comparison of TCM syndrome integral:?1?The total score comparison of TCM syndromesIntra-group comparison of total TCM syndrome scores of the observation group and the control group before and after treatment showed statistically significant differences?P<0.01?.Comparison of total TCM syndrome scores of the two groups after treatment showed statistically significant differences?P<0.01?.?2?Score comparison of main symptoms of TCM syndromesScore comparison of main symptoms of TCM syndrome between the observation group and the control group before and after treatment showed statistical significance?P<0.01?.Score comparison of main symptoms of TCM syndrome between the two groups after treatment showed statistical significance?P<0.05?.?3?Comparison of TCM syndrome scoresIntra-group comparison of TCM syndrome scores between the observation group and the control group before and after treatment showed statistically significant differences?P<0.01?.Comparison of TCM syndrome scores between the two groups after treatment showed no statistically significant differences?P<0.05?.?4?Comparison of scores of single symptoms in sub-syndromesIntra-group comparison of scores of single symptoms before and after treatment in the observation group.Except for"hypolibido",the differences of scores of single symptoms in other cases were statistically significant?P<0.05?.In the control group,single symptom scores were compared before and after treatment.Except for"dry mouth and no desire to drink",the differences of single symptom scores were statistically significant?P<0.05?.After treatment,the single symptom scores of the two groups were compared between the two groups,and the changes of"color,blood clot,lumbar and knee tenderness,lower abdominal distention pain or lower back tingling,fear of cold and fear of cold,upset insomnia,five upset heat,premenstrual breast distension"were statistically significant?P<0.05?.4.Comparison of serum sex hormone levels:Comparison of serum E2,FSH and LH levels between the observation group and the control group before and after treatment showed no statistically significant difference?P>0.05?,while comparison of serum E2,FSH and LH levels between the two groups showed no statistically significant difference?P>0.05?.Comparison of serum FSH/LH level in the observation group before and after treatment showed statistically significant difference?P<0.01?.Comparison of serum FSH/LH level in the control group before and after treatment showed no statistically significant difference?P>0.05?.Comparison of serum FSH/LH level in the two groups after treatment showed no statistically significant difference?P>0.05?.5.The comparison of the curative effect of TCM syndromes:After treatment,the total curative effective rate of the treatment group was 88.6%,and that of the control group was 74.3%.The chi-square test showed that the difference was not statistically significant?P>0.05?.In the evaluation of efficacy grade,3 patients in the treatment group recovered,17 patients showed significant effect,11 patients were effective,and 4 patients were ineffective,with a recovery rate of 57.1%.In the control group,1 case was cured,9 cases were significantly effective,16 cases were effective,and 9 cases were not.The increasing penetrance rate was 28.6%.By rank-sum test,the difference was statistically significant?P<0.05?.Conclusion:The clinical effect of kidney-nourishing and blood-activating decoction and guishen pills on Hypomenorrhea with kidney deficiency syndrome is definite.Both of them can significantly improve clinical symptoms,increase menstrual volume and improve the level of E₂,and the treatment group is better than the control group.In the treatment group,the level of FSH/LH could be adjusted.The two groups had the same effect in improving endometrial thickness in mid-luteal phase.