| ObjectiveTo conduct a large sample survey of TCM Syndromes of Taiwan hypomenorrhea distribution,understand the TCM type distribution in Taiwan area too little menstruation.And to explore the TCM etiology and pathogenesis analysis of Taiwan hypomenorrhea,provide a theoretical basis for clinical treatment of hypomenorrhea.Clinical efficacy and study of Guishen Pill Treatment of hypomenorrhea,provide the experiment is based on traditional Chinese medicine treatment of hypomenorrhea.Methods(1)Through the network literature review,research progress in the understanding of hypomenorrhea.The results of this disease research,combined with the current etiology,pathogenesis,TCM treatment,determine the design ideas,clarify the research project,set up a scientific and effective questionnaire.During December 2014 to December 2016 in Taiwan were collected in our hospital Chinese medicine clinic of 200 patients with hypomenorrhea.In 200 cases of female menstrual history,life history,medical history,family history were retrospectively investigated,detailed record.A unified questionnaire into the computer to form a database package.The data management and statistics by using SPSS17.0 software.The age of onset,duration,number of pregnancy,method of analysis of frequency of intrauterine operation times by PEARSON X2.Test and Mann-Whitney U test analysis of syndrome distribution of hypomenorrhea with age,disease duration,number of pregnancy,intrauterine operation times and explore correlation Please close the system between the syndrome distribution and pathogenic factors of the two,and analyze the reasons?(2)Use Guishen Pill in the treatment of kidney deficiency hypomenorrhea,a commonly used Shugan Jieyu medicine Xiaoyao Powder as control group,observe two groups of the total efficiency,menstrual volume,endometrial thickness and changes in patients with hormone therapy,explore effective ways of hypomenorrhea,provide the experimental basis for Chinese medicine treatment of hypomenorrhea.Results(1)hypomenorrhea patients in Taiwan area incidence in women of childbearing age to see,28-34 age incidence rate than other age groups.(2)191 cases of hypomenorrhea patients in Taiwan the shortest duration of 3 months,the longest duration of 12 years.The patients whose disease duration of less than 12 months were 74 which was 38.74%of the total patients;There were 68 cases in the course of the disease from December to 24,accounting for 35.6%,and the duration of the disease was between 24 and 36 months,with a total of 32 cases,accounting for more than 16.75%,with a course of more than 36 months(accounting for 8.91%).Most of the patients whose duration of the disease was less than 24 months.(3)191 cases of pregnancy in patients with hypomenorrhea times up to 6 times,0 times of pregnancy for 32 cases accounted for 16.75%of the total;1 times in 34 cases accounted for 17.8%of the total number of cases of pregnancy;pregnancy 2 times in 44 cases,accounting for 23.03%of the total number of pregnancy;more than 3 times in 81 cases accounted for 42.40%of the total.From the survey results,the more the number of pregnancies,the incidence of the disease showed an upward trend.(4)Taiwan area hypomenorrhea survey see intrauterine operation times 92 cases accounted for 48.17%of the total 0 times,accounting for almost half of the total number of respondents;intrauterine operation 1 times in 19 cases accounted for 10%of the total number of cases of uterine cavity operation;2 times were 23 cases,accounting for 12.04%of the total;uterine cavity in the operation of more than 3 times the number of 57 cases accounted for 29.84%of the total.According to the results of the survey,because of the protection of the law of eugenic protection and the protection of the fetus,the operation rate of uterine cavity in Taiwan area was significantly less than that of mainland china.Nearly half of the investigators did not have a history of endovascular surgery,but in the investigation of the history of uterine cavity operation,we can see that the number of intrauterine operation,the incidence of the disease increased.(5)191 cases of patients with abnormal menstruation in Taiwan,the proportion of patients with kidney deficiency is the largest,reaching 31.94%,followed by liver depression and blood stasis,respectively,and 19.90%and 15.18%.The phlegm dampness type accounted for 14.70%;the blood deficiency type was 12.04%,and the proportion of blood cold was only about 1%.61 cases of kidney deficiency patients with kidney qi deficiency syndrome accounted for the total number of 30 cases of 49.18%.Kidney yin deficiency syndrome for 25 cases,accounting for 40.98%;kidney yang deficiency syndrome in only 6 cases,accounting for 9.83%.In 191 cases,the proportion of deficiency syndrome was the largest in 121 cases,which was up to 63.35%,and the positive rate was in the presence of a total of 38 cases(accounting for 19.90%)in all cases,accounting for the total number of cases(32)(6)(6)there was no statistical difference in the distribution of syndrome types in different age groups in Taiwan area,which showed that there was no correlation between the syndrome types and age.(7)There was no statistical difference in the distribution of syndrome types in patients with different duration of disease in Taiwan area.(8)there was a significant difference in the distribution of the number of pregnancies in the Taiwan area,which showed that there was a correlation between the number of pregnancies and the distribution of syndrome types.The results showed that there was a correlation between the number of pregnancies and kidney deficiency syndrome,and the greater the number of pregnancy,the greater the possibility of kidney deficiency syndrome.22.There was no significant correlation between the distribution of other syndromes and the number of pregnancy.(9)here was a significant difference in the distribution of syndrome types in the patients who had too much time in the uterine cavity operation in Taiwan area.Further tests were carried out in 22.The results showed that the number of intrauterine operation was related to blood stasis syndrome,and the number of patients with intrauterine operation was more and more likely to have blood stasis syndrome.The number of intrauterine operation was associated with kidney deficiency syndrome,and the greater the number of patients with intrauterine operation,the greater the possibility of kidney deficiency syndrome.There was no significant correlation between the distribution of other syndromes and the number of pregnancy.(10)The total effective rate was 96.67%in the treatment of kidney deficiency and stagnation of liver Qi type,and the total effective rate of Xiaoyao Powder in treating kidney deficiency and stagnation of liver Qi type was less than 83.33%.The difference between the two groups was tested by rank sum test,Z=-3.162 P=0.015,P<<0.05>>.The results showed that the clinical efficacy of two groups were different,and the effect was better than Xiaoyao powder.(Table 2)(11)Kidney deficiency hypomenorrhea patients treated with Guishen Pill Treatment after menstruation than before treatment increased,while Xiaoyaosan can also increase kidney deficiency hypomenorrhea patients with menstrual quantity,the study also found that the increase of Guishen Pill on kidney deficiency patients with stagnation of the liver Qi menstrual quantity of Xiaoyao Powder is better than.(Table 3)(12)Liver kidney hypomenorrhea patients Guishen Pill Treatment of endometrial thickness increased than before treatment,at the same time Xiaoyao Powder can also increase the kidney deficiency hypomenorrhea patients with endometrial thickness,the study also found that the increase of Guishen Pill Shenxu Ganyu patients with endometrial thickness ratio of Xiaoyao Powder has better effect.(Table 4)(13)Guishen pill and Xiaoyao Powder can improve the level of E2 in patients with kidney deficiency and stagnation of liver qi,and the results are quite good.However,there is little effect on FSH,LH,P and PRL levels in kidney deficiency and stagnation of liver Qi type in patients with kidney deficiency and liver stagnation.Conclusion:(1)aiwan area is too small to patients with deficiency syndrome,of which the most common type of kidney deficiency.Kidney deficiency syndrome in patients with kidney qi deficiency and kidney yin deficiency.Kidney deficiency is associated with less menstruation,the more serious the degree of kidney deficiency,the more obvious the decrease of menstrual volume.There was a significant relationship between kidney deficiency and the number of pregnancy and intrauterine operation.The more times of pregnancy,the greater the number of intrauterine operation,the loss of kidney qi is also more serious.(2)In Taiwan area,the incidence of liver depression is only second to that of kidney deficiency.Common kidney deficiency and stagnation of liver.Confirmed the "liver and kidney homology" theory.Treatment of liver and kidney in clinical treatment.(3)Blood deficiency and blood stasis are common syndromes in Taiwan area,but the cold type is rare.The reason is that Taiwan is located in the south of the Five Ridges area,is a subtropical climate,hot and humid weather more common,so cold blood type is rare.(4)The results show that the total effective rate of the treatment of kidney deficiency and stagnation of liver Qi type is high and the safety is good.(5)The Guishen pill can improve the level of E2 in the patients and increase the thickness of endometrial,so as to achieve the effect of increasing menstrual volume. |
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