A Clinical Study Of Guiqitengcao Ointment In The External Treatment Of White Lesions Of The Vulva (blood Deficiency And Dampness Syndrome)

Objective:To evaluate the clinical efficacy of Guiqi Tengcao Ointment in the treatment of blood-deficiency and dampness-type vulvar white lesions by randomized clinical controlled study,and to select the outcome evaluation index that directly affects patients.The mechanism of action of treating white lesions of the vulva and further explore the pathogenesis of white lesions of the vulva will be explored.Methods:A total of 64 patients with vulvar white blood lesions and blood-deficiency syndromes were collected from the Dongfang Hospital of Beijing University of Traditional Chinese Medicine,Beijing Huairou Chinese Medicine Hospital and Beijing Haidian District Hospital of Traditional Chinese Medicine.A randomized controlled study was conducted to divide patients.For the experimental group and the control group,the external treatment of Guiqitocao ointment and hypocrellin ointment was used respectively.The observation of the improvement of vulvar lesions,TCM syndrome scores,pathological examination and other indicators was used to verify the external treatment of Guiqi Tengcao Ointment.The efficacy of the disease.Results:The total effective rate of the two groups before and after treatment was 66%in the experimental group and 38%in the control group.The difference was statistically significant(p<0.05),indicating that the treatment was effective in both groups;The differences between the groups were statistically significant(p<0.05),indicating that the overall efficacy of the test group for the white lesions of the vulva was better than that of the control group.The VAS score of pruritus before and after treatment was compared between the two groups,and the effective rate was 88%in the experimental group and 66%in the control group.The VAS score of pruritus after treatment was statistically significant compared with those before treatment,indicating that treatment can improve the symptoms of pruritus(P<0.05).The difference between the two groups was statistically significant(P<0.05),indicating that the experimental group was better than the control group in improving itching.The main clinical symptoms of the two groups before and after treatment were improved,and the difference was statistically significant,suggesting that both treatments can improve the main clinical symptoms such as itching and hypopigmentation(P<0.05).Comparing the two groups,the experimental group treated the white lesions of the vulva better.The curative effect was significantly better than the control group,and the difference was statistically significant(P<0.05).However,the improvement is given priority to with the itch.Considering the long-term hypopigmentation,it is difficult to achieve a visually significant effect in a short period of time(3 months).Through the CIE Lab color system,the color of the lesion skin is quantitatively compared to obtain a treatment pair.The a*value(a*value indicates a change in color from green(-a*)to red(+a*)is statistically significant,showing that medication can improve the degree of rosy skin lesions.For the improvement of TCM syndrome scores,the TCM syndrome score before treatment was 15.22±3.87 in experimental group,and the TCM syndrome score before treatment was 14.13±2.84 in control group.The control group score was slightly lower than the test group,but the difference between the two groups was not obvious(p>0.05).The TCM syndrome scores of the two groups were significantly lower than those before treatment.The scores of the experimental group were 8.7813.39,and the TCM syndrome scores of the control group were 10.63±3.01.There were significant differences between the two groups before and after treatment(p<0.01).Comparing the two groups,the treatment group was significantly better than the control group,the difference was significant(p<0.01).CONCLUSION:Guiqi Tengcao Ointment is used to treat the bloody and dampness syndrome of white lesions of the vulva,so as to improve the degree of itching.The overall curative effect,itching effect,clinical symptoms,and TCM symptoms are better than the hypocrellin ointment.Guiqi Tengcao ointment is effective in treating vulvar white lesions with blood deficiency and dampness syndrome.The treatment method is simple and convenient to use,and can be further promoted to the community to improve the quality of life of patients with white lesions of the vulva.