| The white lesions of vulva, also called vulvar dystrophy, is one of the common disease in elder women, which leads to the disorder of growth of epidermis tissues and degeneration of dermis. It is a chronic skin disease characterized by vulva pruritus, skin depigmentation, atrophy of vulva, narrow vaginal orifice and pain during coitus at the late stage. The malignant rate was 2~5%. Because of the particular location, the treatment of white lesion of vulva is one of the most troublesome problems in gynecology. Local medication with hormone is still the main treatment method. But the recurrence rate is high. The pruritus seriously affects patient's life quality. So it is imperative to develop new and effective treatment.Based on preliminary investigations, we applied ultrasound wave to treat the white lesions of vulva since 1999. This paper reports the clinical and pathological changes of the white lesions of vulva after ultrasound treatment.Part 1The Relationship between the ultrasound therapeutic dose and efficacy on the skin of rabbitObjective: To investigate the effect and safety on the skin of the rabbit with ultrasound treatment Methods: 1. Seventy-six rabbits were sonicated 2. Scan: 66 rabbits. Single exposure: 10 rabbits. 3. 30 of the 66 rabbits were randomly divided into five groups: the power of scan for each group (n=6) was 6W, 7W, 8W, 9W and 10W, respectively. 4.After treatment, the skin of rabbits was stained with Triphenyl tetrazolium chloride (TTC) and pathological examinations were performed. Result: 1.While the frequency of the scan was 5~8MHz, the power of the scan was less than 9W, the scan speed was 2-3mm/sec, transient hyperemia and edema appeared on the skin of rabbits, suggesting the safety of ultrasound therapy. 2.While exposure duration was beyond 2sec, or the power of the scan was more than 10W, it resulted in coagulation necrosis of dermis. 3.After the treatment, the skin of the rabbits only appeared the transient hyperemia and edema without any lesion and could return to normal completely.Conclusion: The control system of the ultrasound device enables adjustment of focus and acoustic power that is appropriate to the treatment, ensuring the reliability and safety of the ultrasound treatment.If the frequency of the scaning was 10MHz and the power of the scaning was less than 9W and the scaning speed was 2-3mm/sec, the ultrasound treatment is safe. Part 2Clinical study of white lesions of vulva by ultrasound treatment1 A therapeutic dosage study of the ultrasound therapy on the white lesions of vulvaObjective: To investigate the relationship between the ultrasound therapeutic dosage and clinical efficacy on the white lesions of the vulva. Methods:1.30 patients with the white lesions of the vulva were randomly divided into different ultrasound treatment groups. Ultrasound energies were 240 to 360 s/cm2. 2.Pathologicalchange of vulvar skin was observed and compared after different ultrasound energies treatment. Results: In following period, the patients recovered at various degrees after ultrasound treatment. 1.The data demonstrated the different dosage and time-intervals of ultrasound treatment resulted in different clinical efficacy on the white lesions of the vulva. 2.There was no significant difference between different histology types of the white lesions of vulva.Conclusions: Under definite therapeutic dosage: the white lesions of vulva can be treated with ultrasound safely, the integrality of the skin of the vulva was preserved during and after treatment. 2. Clinical study of the white lesions of vulva by ultrasound treatmentObjective: To investigate clinical effect after ultrasound therapy.Methods:1.One hundred patients with the white lesions of the vulva were observed. The histology type involved fifty-six cases of squamous cell hyperplasia, thirty-one cases of lichen sclerosis and four cases of VIN (vulva intra-epithelial neoplasia). 2.Forty of them we...
|
PDF Full Text Request