| Purpose:To observe the effect of compound radix sophorae injection combined with zoledronic acid on the pain of bone metastasis of NSCLC.Material and method:Collection in November 2016 to January 2019 in liaoning province tumor hospital medical ward for treatment,the pathology diagnosed with non-small cell lung cancer with bone metastasis of 100 patients.According to different treatment protocols,there are 50 cases of control group and 50 cases of treatment group.The control group included 50 patients,including 34 male patients and 16 female patients.The treatment group included 50 patients,including 35 male patients and 15 female patients.The age range is in the range of 40 to 76years.The control group has an average age of 61.88±8.33 years,and the average age of the treatment group is 61.44±8.52 years old.There was no significant difference between the two groups in gender,age,pathological classification,bone metastasis site,course of disease and other basic conditions(p>0.05).Before treatment,there was no significant difference in the observation indexes(KPS score,VAS score,whether to use painkillers systematically and regularly)between the two groups(p>0.05).The specific situation is as follows:(1)Bone metastasis was confirmed by bone scan(or CT,MRI,PET/CT)and other imaging examinations,and the specific location of bone metastasis was identified;all patients had moderate or above pain symptoms.(2)Grouping criteria:on the basis of non-small cell lung cancer GP chemotherapy,the control group was treated with zoledronic acid monotherapy;The treatment group was treated with zoledronic acid plus compound radix sophorae injection.(3)Observe the pain relief and quality of life improvement of the two groups of patients after treatment.Results SPSS19.0 statistical software was used for calculation,(?)±S was used for description of measurement data,independent sample t test was used for comparison between measurement data groups with normal distribution,paired t test was used for comparison of results before and after intra-group treatment,and non-parametric test was used for comparison of measurement data without normal distribution.X~2 test was used to compare the counting data,and p<0.05 was considered statistically significant.Results:1.The pain of the patients in the control group and the treatment group was relieved after treatment,and the pain relief in the treatment group was significantly lower than that in the observation group,with statistically significant difference(p<0.05).2.The treatment group after two weeks of analgesics used dose in patients with a reduction of50%or more than the control group,the treatment effect is better than the control group,difference has statistical significance(p<0.05).3.The physical changes of the patient after treatment of the treatment group were obviously changed obviously,the improvement was higher than that of the control group,and the difference was statistically significant(p<0.05).4.The number of patients with improved quality of life in the treatment group was more than that in the control group,and the difference was statistically significant(p<0.05).5.The incidence of non-chemotherapy adverse reactions in the treatment group was lower than that in the control group,and the difference was statistically significant(p<0.05).Conclusion:1.Compound kushen injection can effectively relieve pain caused by bone metastasis.2.Compound kushen injection can enhance the physical condition of patients.3.Compound kushen injection can improve the quality of life of patients.4.Compound kushen injection can alleviate the adverse reactions of zoledronic acid. |
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