Studies On The Chemical Constituents Of Horsfieldia Kingii

This dissertation mainly reported chemical constituents of the medicinal plant Horsfieldia kingii.Totally 71 compounds were isolated and identified from this plant.By means of various chromatography methods and spectroscopic evidences,71compounds were isolated and identified from this plant.The compounds were elucidatedasmethyl2-（（5,7-dimethoxy-1-oxo-1,3-dihydroisobenzofuran-4-yl）oxy）-4-methoxy-3,6-dimeth ylbenzoate（1）,virolanolC（2）,1-（3’,4’-methylenedioxyphenyl）-3-（2’’-hydroxy-4’’-methoxyphenyl）-propan-2-ol（3）,1-（4’-hydroxy-3’-methoxyphenyl）-3-（2’’-hydroxy-4’’-methoxyphenyl）-propane（4）,thero-2,3-bis-（4-hydroxy-3-methoxypheyl）-3-methoxy-propanol（5）,evofolin B（6）,1,2-bis（4-hydroxy-3-methoxyphenyl）-1-propanone（7）,α,2’-dihydroxy-4,4’-dimethoxydihydrochalcone（8）,isoliquiritigenin（9）,2’,4’-dihydroxy chalcone（10）,butin（11）,liquiritigenin（12）,eriodictyol（13）,naringenin（14）,7-hydroxyflavonone（15）,pinocembrin（16）,tectorigenin（17）,iristectorigenin A（18）,prunetin（19）,biochanin A（20）,formononetin（21）,irilone（22）,genistein（23）,2’-hydroxyformononetin（24）,4’,7-dihydroxy-3’,6-dimethoxyisoflavone（25）,irisolidone（26）,calycosin（27）,apigenin（28）,chrysoeriol（29）,luteolin（30）,4’,7-dihydroxyflavone（31）,3’,4’,7-trihydroxyflavone（32）,kaempferol（33）,resokaempferol（34）,quercetin（35）,3’,4’,3,7-tetrahydroxyflavone（36）,astragalin（37）,kaempferol-3-O-β-_D-6’-acetylglucopyranoside（38）,（+）-dihydrokaempferol（39）,3,5,7,3’,5’-pentahydroxydihydroflavonol（40）,dihydroquercetin（41）,（-）-3,4’,7-trihydroxy-3’-methoxyflavan（42）,medicarpin（43）,epiphyllocoumarin（44）,hydnocarpin（45）,2,6-dihydroxy-2-[（4-hydroxyphenyl）methyl]-3-benzofuranone（46）,cinchonain Ib（47）,loropetaliside A（48）,psoromic acid（49）,hainanmurpanin（50）,murralongin（51）,medioresinol（52）,（+）-syringaresinol（53）,pinoresinol（54）,falandin B（55）,dihydrophaseic acid（56）,8,8′-bis-（dihydroconiferyl）-diferuloylate（57）,3,4-dihydroxy-cinnamicacid（58）,C-veratroylglycol（59）,2,3-dihydroxy-1-（4-hydroxyl-3,5-dimethoxyphenyl）-1-propanone（60）,β-hydroxypropiovanillone（61）,ferulic acid（62）,1-（4-hydroxy-3-methoxyphenyl）propan-1,2-diol（63）,2-guaiacylpropane-1,3-diol（64）,berfussinol（65）,syringic acid（66）,methyl protocatechuate（67）,vanillin（68）,3,4-dihydroxybenzoic acid（69）,1,2,4-trihydroxybenzene（70）,p-hydroxybenzoic acid（71）.Compound 1 is a new compound,Compounds 5,7,10,25-26,28-29,31,36-39,42-52,55-56,58-65,68,70-71 were isolated from Horsfieldia genus for the first time.Moreover,compounds6,9,13-14,23,33-34,41,54,66 were isolated from the Horsfieldia kingii for the first time.In the end,the chemical constituents and biological activities of lignans from species belonging to Myristicaceae family were summarized.