| Objective:Canine pancreatitis is an acute inflammation caused by trypsin digestion of its own tissues.Due to the abnormal exocrine function of the pancreas,the "self digestion" of the pancreas leads to the edema,hemorrhage and necrosis of the pancreas;the clinical symptoms are not characteristic,most of which are vomiting,diarrhea,abdominal pain,peritonitis,shock and other symptoms,which are easy to be misdiagnosed and lead to kidney failure,liver failure,diabetes and other secondary diseases.In this study,the incidence of canine pancreatitis was investigated in an animal hospital in Urumqi,and the clinical treatment of typical cases and cases with renal failure was carried out,providing reference for the pathogenesis and clinical diagnosis and treatment of canine pancreatitis.Methods:The incidence rate of canine pancreatitis in outpatients of digestive tract symptoms in an animal hospital in Urumqi from January 2019 to January 2020 was investigated by field epidemiology.Statistical analysis of the age distribution,species,gender,etiology,main clinical symptoms of pancreatitis in dogs,to provide clinical data for the pathogenesis of pancreatitis in dogs.24 typical cases of canine pancreatitis were treated with contrast therapy.One group was treated with ulinastatin(2000 IU / kg)and the other group was treated with octreotide acetate(0.1mg / kg),.There were 12 cases in each group.Analyze the treatment course and cure rate.Eight cases of pancreatitis complicated with renal failure were treated with antibiotic,anti-inflammatory,correction of body fluid balance and inhibition of pancreatic secretion.Results:Canine pancreatitis accounted for 6.82%(35/513)of outpatient cases with gastrointestinal symptoms.Among the 35 confirmed cases of canine pancreatitis,60.00%(21/35)were female and 40.00%(14/35)were male.51.43%(18/35)were dogs over 5 years old and14.28%(5/35)were dogs under 1 year old.Distribution of species: the highest proportion of Teddy dogs was 25.71%(9/35),and the second proportion of hybrid dogs was 22.86%(8/35).Etiology:the incidence of long-term feeding of meat and other foods was 51.43%(18/350.Clinical symptoms: 100%(35/35)of the dogs with inappetence,85.71%(30/35)of the dogs with abdominal pain,65.71%(23/35)of the dogs with vomiting;blood routine examination: 54.29%(19/35)of the dogs with white blood cells on the high side,20.00%(7/35)of the dogs with erythrocytopenia.Blood biochemical examination: 91.43%(29/35)of the dogs had high serum amylase,97.14%(34/35)had high lipase,34.28%(12/35)had high urea and 25.71%(9/35)had high creatinine.22.86%(8/35)of the cases were complicated with kidney injury,14.29%(5/35)with diabetes,and 8.57%(3/35)with liver function injury.54.28%(19/35)of the dogs had elevated C-CRP,and most of the dogs with organ failure had moderate or above infection.The results of clinical grouping showed that there was a significant difference in the days of cure between the Ulinastatin treatment group(6.42±1.31 d)and octreotide acetate treatment group(7.91±2.19 d)(P<0.05).The effective rate was 83.33% in the Ulinastatin group and 66.67% in the octreotide acetate group.Eight cases of canine pancreatitis complicated with renal failure were treated with comprehensive treatment of ulinastatin for injection,ampicillin sodium,omeprazole sodium,serenin and other drugs,and the cure rate was 62.50%(5/8).Conclusion:Canine pancreatitis occurs all year round,and can occur in all genders and breeds.The incidence of canine pancreatitis is higher in dogs over 5 years old,and the main clinical symptoms are abdominal pain.The increase of lipase and amylase in biochemical examination is of great significance for the diagnosis of canine pancreatitis.At the same time,combined with the increase of creatinine and urea,the diagnosis of pancreatitis complicated by renal failure can be confirmed.The results of C-CRP in measurement in dogs have reference value for the prognosis of the disease.Ulinastatin was superior to octreotide acetate in the treatment days and cure rate of canine pancreatitis. |
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