| Objective :To investigate the effect of Zhishang Yifang addition and subtraction combined with apixaban on postoperative hypercoagulability and postoperative swelling and pain in patients with femoral shaft fractures,and to provide certain reference and basis for improving postoperative hypercoagulability and preventing thrombosis in patients with femoral shaft fractures by traditional Chinese medicine.Methods:Collected 60 cases of hospitalized patients with femoral shaft fractures treated by internal fixation in Department of Orthopedics,the Second Hospital of Fuzhou.The patients were numbered according to the first visit time and divided into experimental group(Zhishang Yifang addition and subtraction combined with apixaban group)and control group(apixaban group)according to the random number table method,with30 cases in each group.D-dimer,thrombelastogram(R value,K value,MA value,Angle value,CI value),VAS pain score and swelling degree of affected limb were observed before operation,1 day,7 days and 14 days after operation,and TCM syndrome scores before operation and 14 days after operation were recorded.SPSS20.0 software was used for statistical analysis of the obtained data.Result:A total of 60 people who met the research criteria were included in this experiment,and 55 cases were finally completed.There were 27 cases in the control group and 28 cases in the experimental group.1.There was no significant difference in gender,age and BMI between the two groups(P <0.05);There was no significant difference in D-dimer,thromboelastography index,VAS pain score,swelling degree and TCM syndrome score between the two groups before treatment.2.D-dimer : two groups can significantly reduce the level of postoperative D-dimer,the difference was statistically significant(P < 0.05),the experimental group than the control group.3.Thrombelastogram : Both groups could significantly prolong the postoperative R value and K value,and reduce the postoperative Angle value,MA value and CI value,with significant difference(P < 0.05).The experimental group was superior to the control group.4.Both groups could significantly reduce the postoperative pain of patients(P <0.05)and reduce the swelling degree of affected limbs(P <0.05),and the experimental group was better than the control group(P < 0.05).5.The TCM syndrome scores of the two groups were significantly improved after operation(P < 0.05),and the experimental group was better than the control group(P < 0.05).6.There was no significant difference in the incidence of postoperative thrombosis between the two groups(P < 0.05).Conclusion:Compared with the simple use of apixaban,Zhishang Yifang addition and subtraction combined with apixaban has better clinical efficacy in reducing the hypercoagulable state of patients after femoral shaft fractures,alleviating postoperative swelling and pain,and reducing the risk of lower limb thrombosis. |
