The Comparative Studies About The Treatment Effect Of The Therapy Of Invigorating The Spleen And Kidney And Eliminating The Turbid By Purgation On Chronic Kidney Disease Fifth Stage (Non-dialysis)

ObjectiveTo observe whether the therapy of Invigorating the spleen and kidney and Eliminating the Turbid by Purgation are effective on Chronic Kidney Disease fifth stage(non-dialysis),by comparing the treatment Effect of combination of Chinese traditional medicine and Western medicine with that of Western medicine on Chronic Kidney Disease fifth stage(non-dialysis).MethodBy screening period,to find 40 patients at Chronic Kidney Disease fifth stage(non-dialysis)meeting the test criteria,and divide into combined treating group(the therapy of Invigorating the spleen and kidney and Eliminating the Turbid by Purgation+basic Western medicine treatment)and Western medicine treatment group(basic Western medicine treatment)adopting the method of no-randomized controlled study criteria.Every patients in two groups are offered basic Western medicine treatment,while the combined treating group are offered oral administration of Bushen Jianpi Decoction and to eliminate the Turbid by Purgation according to their own willing as well as clinical conditions.This test lasts for six months for every patient,in this period they must go for a return visit for a comprehensive review of his or her symptoms and signs respectively every months(view 28±3 days as one month),and go for clinical efficacy evaluation and review the relevant laboratory parameters every two months.Main evaluation parameters include creatinine,glomerular filtration rate and albumin、hemoglobin.Base on the last test result,a statistical analysis can be carried out.Result1.There are 40 patients in all,each group includes 20 patients.In combined treating group,there is 1 case to fall off and 2 cases ended.In Western medicine treatment group,there are 2 cases ended.AS a result,there are 35 cases from two groups entered the analytic stage.2.At the end of six months after treatment started,the SCr of combined treating group has no statistical significance compared with the difference before treatment(P=0.365);while the SCr of Western medicine treatment group increases significantly and has statistical significance compared with the difference before treatment(P<0.05)The difference between the two groups after treatment has statistical significance(P<0.05).3.At the end of six months after treatment started,the eGFR of combined treating group has no statistical significance compared with the difference before treatment(P=0.701);while the eGFR of Western medicine treatment group decreases significantly and has statistical significance compared with the difference before treatment(P<0.05)The difference between the two groups after treatment has statistical significance(P<0.05).4.At the end of six months after treatment started,the Alb of combined treating group has no statistical significance compared with the difference before treatment(P=0.701);while the Alb of Western medicine treatment group decreases significantly and has statistical significance compared with the difference before treatment(P<0.05).The difference between the two groups after treatment has no statistical significance(P>0.05).5.At the end of six months after treatment started,the HGB of combined treating group has no statistical significance compared with the difference before treatment(P=0.942);the HGB of Western medicine treatment group has no statistical significance compared with the difference before treatment(P=0.079).The difference between the two groups after treatment has no statistical significance(P>0.05).6.At the end of six months after treatment started,the traditional Chinese medicine syndrome rating of combined treating group decreases significantly and has statistical significance compared with the difference before treatment(P=0.004);while the traditional Chinese medicine syndrome rating of Western medicine treatment group has no statistical significance compared with the difference before treatment(P=0.204).The difference between the two groups after treatment has no statistical significance(P>0.05).In conclusion1.In the treatment of chronic Kidney Disease fifth stage(non-dialysis),the therapy of Invigorating the spleen and kidney and Eliminating the Turbid by Purgation not only delayed the deterioration of the renal function(reduced SCr and enhance eGFR),but also control the serum albumin level significantly and delay the descending rate of HGB.2.In the treatment of chronic Kidney Disease fifth stage(non-dialysis),the therapy of Invigorating the spleen and kidney and Eliminating the Turbid by Purgation improved the clinical symptoms and living quality of Chronic Kidney Disease fifth stage patients without any adverse reactions.