Clinical Study About The Method Of Opening The Orifices Of The Fu Organs Combined Rt-PA Intravenous Thrombolytic Treat Early Ischemic Stroke

Objective: To observe and analyze the purgation and resuscitation method combined with alteplase(rt-PA)effect of ultra early intravenous thrombolytic therapy for ischemic stroke,to explore the mechanism of action,efficacy,safety and other issues,to provide reference for further clinical application in the treatment of ischemic stroke.Methods: 63 patients who met the inclusion criteria were randomly divided into two groups: the control group and the observation group,with 1 cases in the control group,and 31 cases in each group.There was no statistical difference between the two groups before treatment,and there was no statistical difference in the proportion of light stroke(NIHSS score < 7).The two groups were treated with rt-PA intravenous thrombolytic therapy and routine treatment.The observation group was treated with traditional Chinese medicine on the basis of the above treatment.After two weeks of treatment,statistics and neurological symptoms were compared between the two groups score(NIHSS score),light stroke ratio,TCM syndrome score and high sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)and other related laboratory indexes,the curative effect and safety evaluation.Results: after treatment,two groups of patients with neurological deficits were improved(P<0.01),the observation group more obvious effectthan the control group(P< 0.05);the proportion of light stroke were compared between two groups after treatment,the observation group was higher than that of control group(P< 0.01);in the observation group curative effect criteria the data is more effective than the control group(P< 0.01),and the effective rate of the treatment was higher than the control group(P<0.05);TCM syndrome score to judge the curative effect of the observation group compared with the control group improved significantly(P<0.01),and the effective rate of the treatment was higher than the control group(P< 0.05).After treatment,the two groups of laboratory indexes were improved,and the improvement of the observation group was more significant than that of the observation group(P<0.01).Comparison of laboratory safety related indexes before and after treatment in two groups showed no significant change(P<0.05),the control group after thrombolysis in 1 cases of intracranial hemorrhage,2 cases of gingival bleeding;observation group after thrombolysis in 1 cases of intracranial hemorrhage,3 cases of subcutaneous ecchymosis.The amount of intracranial hemorrhage in the two groups was less than 5ml,and the bleeding was distributed in a point form.The bleeding site was located at the infarct site,and the bleeding was absorbed after conservative treatment.There were no adverse reactions such as diarrhea,allergy,nausea and vomiting in the two groups.There was no significant difference in the number of adverse reactions between the two groups(P>0.05).Conclusion: purgation and resuscitation therapy combined with rt-PA intravenous thrombolytic therapy for hyperacute ischemic stroke,compared with the simple application of rt-PA intravenous thrombolytic therapy,can significantly improve the patient’s neurological symptoms,improve the prognosis and reduce the disability rate,and no obvious side effect,high safety,and is worthy of clinical research.