Correlation Analysis Between Tcm Syndrome Differentiation And NLR PLR Of Non-puerperal Mastitis

Objective:1.To research the relevance of NLR,PLR and the occurrence of non-puerperal mastitis.2.To explore the correlation between different TCM syndrome types of non lactation mastitis and related laboratory indexes and clinical symptoms.3.To discusse the difference of NLR,PLR expression in different TCM syndromes of NPM.Methods:105 cases of non lactation mastitis patients and health examination patients were selected to meet the criteria.The epidemic questionnaire and clinical observation table of TCM Syndromes of non-puerperal mastitis were filled in.NLR,PLR,hs-CRP,ESR,PRL and blood routine were collected from the diseased group and the health control group.The age,NLR,PLR,hs-CRP,ESR,WBC,N,L and PLT of the two groups were compared..105 patients were divided into positive and evil Love syndrome,Yang deficiency phlegm coagulation syndrome,phlegm stasis syndrome,liver meridian heat stagnation syndrome and heat poison blazing syndrome.The correlation between NLR,PLR and general data,abscess,mass,pain score and hs-CRP,ESR and WBC were analyzed in 105 patients.The relationship between NLR,PLR and TCM syndrome differentiation of non-puerperal mastitis was analyzed in 105 patients.Statistical analysis of data by SPSS v21.0 software.Results:1.The levels of hs-CRP,ESR,WBC,NLR,PLR,PLT and N in patients were higher than healthy person,while the level of L in patients was lower than healthy person.2.AUC of NLR predicting NPM was 0.915(95% CI: 0.876-0.954,(49)<0.05),the best critical value was 2.162,sensitivity and specificity were 88.6% and 83.8%,respectively.AUC of PLR predicting GM was 0.751(95% CI: 0.684-0.818,(49)<0.05),the best critical value was 122.461,sensitivity and specificity were 76.2% and 71.4%,respectively.3.Taking illness as dependent variable,NLR ≥ 2.162,PLR ≥ 122.461(Youden coefficient calculated according to ROC curve)as independent variable,multivariate logistic regression analysis showed that NLR ≥ 2.162,PLR ≥ 122.461 were risk factors of NPM.4.The study found that there was no difference in the proportion of different TCM syndrome types of 105 NPM patients in age and history of lactation disorder,but there were differences in pathological type,prolactin level and inverted nipple.The proportion of positive deficiency and evil Love syndrome was the highest in patients with pathological granulomatous mastitis,and the proportion of Yang deficiency and phlegm coagulation syndrome was higher in patients with pathological plasma cell mastitis;Among the patients with high prolactin level,stagnation heat syndrome of liver meridian accounted for the highest proportion;Among the patients with inverted nipple,the proportion of heat toxin is the highest.5.There were differences in mass score,abscess score and pain score among different TCM syndromes,and the mass score of liver meridian stagnation heat syndrome was the highest;The abscess score of liver meridian stagnation heat syndrome was the highest;The pain score of patients with liver meridian stagnation heat syndrome was the highest.6.There were significant differences in the values of hs CRP,ESR,WBC,l and PLT in different TCM syndromes(< 0.05).The hs CRP level of patients with excessive heat toxin syndrome was the highest;ESR and PLT were the highest in patients with excessive heat toxin syndrome;WBC in patients with excessive heat toxin syndrome was higher than that in patients with liver meridian stagnation heat syndrome;The value of l was the highest in the patients with Zheng Xu Xie Lian syndrome.The correlation between NLR,PLR and age,pathology,hyperprolactin,inverted nipple was analyzed.The results showed that NLR had no significant correlation with age,pathology,inverted nipple.NLR was positively correlated with hyperprolactin.There was no significant correlation between PLR and age,pathology,high prolactin level and course of disease.7.The correlation between NLR,PLR and age,pathology,hyperprolactin,inverted nipple was analyzed.The results showed that NLR had no significant correlation with age,pathology,inverted nipple.NLR was positively correlated with hyperprolactin.There was no significant correlation between PLR and age,pathology,high prolactin level and course of disease.8.NLR was positively correlated with abscess score and pain score,but weakly correlated with mass score;There was a moderate positive correlation between PLR and pain score,a weak positive correlation between PLR and abscess score,but no correlation between PLR and mass score.9.Hs-CRP was positively correlated with NLR and PLR,and the correlation coefficients were 0.644 and 0.292,respectively;WBC was positively correlated with NLR,the correlation coefficient was 0.634,but not with PLR;Kendall correlation analysis showed that ESR was positively correlated with NLR and PLR,and the correlation coefficients were 0.404 and 0.234,respectively.10.NLR and PLR values of patients with different TCM syndromes were different,(49)< 0.05,the difference was statistically significant.There were significant differences in NLR values among heat toxin hyperactivity syndrome,liver meridian stagnant heat syndrome and Zheng Xu Xie Lian syndrome.There were no significant differences in NLR values between patients with Yang deficiency and phlegm coagulation syndrome and patients with phlegm stasis syndrome.NLR value of patients with excessive heat toxin syndrome was higher than that of patients with stagnation heat syndrome of liver meridian,and NLR value of patients with stagnation heat syndrome of liver meridian was higher than that of patients with positive deficiency and evil Love syndrome.There were significant differences in PLR values among patients with excessive heat and toxin syndrome,liver meridian stagnation heat syndrome and phlegm stasis syndrome,but there were no significant differences in PLR values among patients with Yang deficiency and phlegm coagulation syndrome and Zheng deficiency and phlegm coagulation syndrome.The PLR value of patients with excessive heat toxin syndrome was higher than that of patients with stagnation heat syndrome of liver meridian,and the PLR value of patients with stagnation heat syndrome of liver meridian was higher than that of patients with phlegm and blood stasis syndrome.Conclusion:1.NLR and PLR can be used as auxiliary indexes and therapeutic evaluation criteria for non lactation mastitis;2.TCM syndrome differentiation,NLR and PLR of patients with non lactation mastitis were correlated with high lactation level,hs CRP,ESR,WBC and clinical symptom score;3.The NLR and PLR values of non lactation mastitis patients are significantly different in the heat toxin excess syndrome and the positive deficiency and evil Love syndrome,which may be used as the objective index of TCM syndrome differentiation of non lactation mastitis.