| Objective: Through the clinical observation of Shenshuaitiaozhong NO.2Decoction in the treatment of chronic renal failure syndrome of stomach yin deficiency and damp-heat,the efficacy and safety of Shenshuaitiaozhong NO.2 Decoction in the treatment of chronic renal failure syndrome of stomach yin deficiency and damp-heat will be discussed,so as to provide new a idea for the treatment of chronic renal failure with integrated traditional Chinese and Western medicine.At the same time,the response degree of the diagnostic scale for the chronic renal failure syndrome of stomach yin deficiency and damp-heat was evaluated to provide better help for the quantitative diagnosis of clinical syndromes of chronic renal failure and judgment of curative effect.Methods:60 patients with stomach yin deficiency and damp-heat in stages 3-5 of chronic kidney disease without renal replacement therapy were randomly assigned to the treatment or control group.On the basis of conventional western medicine treatment,the treatment group used shenshuaitiaozhong NO.2 decoction and the control group used Niaoduqing Particles.The therapy lasted four weeks.Laboratory values such as creatinine,blood urea nitrogen,uric acid,albumin,hemoglobin,electrolytes,and phosphorus,as well as the syndrome quantitative score of chronic renal failure syndrome of stomach yin deficiency and damp-heat,were observed and recorded in the two groups.Results:(1)Comprehensive clinical efficacy: The treatment group achieved an effective rate of 86.67 percent,whereas the control group achieved a rate of 66.67 percent.The treatment group’s total curative effect was superior to that of the control group(P<0.05).(2)Laboratory indicators:Creatinine,blood urea nitrogen,uric acid: compared between the two groups before and after treatment,the creatinine,blood urea nitrogen,and uric acid in the treatment group were decreased(P<0.05),and the creatinine and uric acid in the control group were decreased(P<0.05),there was no significant difference in urea nitrogen(P>0.05).After treatment,the level of creatinine in the treatment group was lower than that in the control group(P<0.05),and there was no significant difference in the levels of urea nitrogen and uric acid between the two groups(P>0.05).Red blood cells,hemoglobin and hematocrit: There was no significant difference in red blood cells,hemoglobin and hematocrit between the two groups before and after treatment(P>0.05).After treatment,there were differences in the levels of red blood cells,hemoglobin and hematocrit between the two groups There was no statistical significance(P > 0.05).Albumin and prealbumin: Compared with the two groups before and after treatment,the treatment group’s albumin improved(P<0.05),prealbumin didn’t change(P>0.05).In the control group,there was no statistically significant change in albumin or prealbumin(P>0.05).After treatment,the effect of the treatment group in increasing albumin was better than that of the control group(P<0.05),and the difference in prealbumin was not statistically significant(P>0.05).Calcium and phosphorus: When the two groups were compared before and after treatment,the treatment group had higher calcium and lower phosphorus levels(P<0.05),calcium and phosphorus levels in the control group didn’t change significantly(P>0.05).After treatment,treatment group increased calcium and decreased phosphorus better than the control group(P<0.05).Electrolytes: The difference in potassium,sodium,chloride,and total carbon dioxide between the two groups was not significant(P>0.05).The treatment group had no significant variation in potassium,chloride,or total carbon dioxide after treatment(P>0.05).The control group had less sodium than the treatment group(P<0.05).24 h urine protein quantification(24QPQ): Compared between the two groups before and after treatment,the 24 QPQ in the treatment group decreased(P<0.05).There was no statistically significant difference in the control group(P>0.05).After treatment,the treatment group’s 24 QPQ level was lower than the control group’s(P<0.05).(3)The curative effect of TCM syndrome: The improvement of TCM symptoms in the dimension of stomach yin deficiency,damp-heat,tongue and pulse in the treatment group were better than those in the control group,and the difference was statistically significant(P<0.05).The effective rate of TCM syndromes was 83.33% in the treatment group and 53.33% in the control group.The effective rate of TCM syndromes in the treatment group was significantly better than that in the control group(P<0.05).(4)In terms of response evaluation: The P values of the stomach yin deficiency,damp-heat and total scale dimensions before and after treatment in the treatment group were all less than 0.05,with significant differences before and after treatment;yellow tongue coating,greasy tongue coating,thick tongue coating,slippery pulse,The P value of several items was less than 0.05,and the difference before and after treatment was statistically significant;the effect scale before and after treatment was 3.32,which was a large effect.(5)Safety evaluation: There were no obvious adverse reactions in the two groups of patients.Conclusions: Shenshuaitiaozhong NO.2 decoction has a good clinical effect on chronic renal failure syndrome of stomach yin deficiency and damp-heat.Compared with the Niaoduqing Particles group,it can significantly reduce the clinical symptoms and quantitative scores of TCM syndromes,and improve the quality of life of the patients,and there are no obvious adverse reactions and side effects.It can be used as a good choice for clinical treatment of chronic renal failure syndrome of stomach yin deficiency and damp-heat.The effect scale of the chronic renal failure syndrome of stomach yin deficiency and damp-heat diagnosis scale is a large effect,and the response degree is good,indicating that the scale can provide better help for the quantitative diagnosis of clinical syndromes and curative effect judgment of chronic renal failure syndrome of stomach yin deficiency and damp-heat. |
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