Observation Of The Clinical Efficacy Of The Addition And Subtraction Of The Qingreyishen Formula In The Treatment Of Renal Deficiency And Damp Heat Hendo-type Hendo-henoch-schrap Purpura Nephritis And Its Effect On Immune Factors And Serum Inflammatory Fa

Objective:To explore the clinical efficacy and safety analysis of renal hypotrophic fever allergic purpuric nephritis(HSPN)by observing the clinical efficacy and safety analysis of renal hypohygomatic fever type henal inflammation(HSPN),and by CRP,IL-6,Ig A,Ig G,C3,C4 and PRO,BLD etc.To try to explore the possible mechanism of self-simulated heat rejuvenation benefit kidney formula in the treatment of renal hypothermia HSPN.Provide further theoretical and practical basis for the treatment of HSPN in traditional Chinese medicine.Methods: With the consent of the Medical Ethics Committee,61 patients with confirmed HSPN and TCM certificates in the outpatient and inpatient departments of Qinghai Hospital of Traditional Chinese Medicine were collected,and they were separated into TCM group and Modern physic group randomly.The treatment group was given self-proposed antipyretic beneficial kidney formula and added or subtracted + valsartan capsules with symptoms,and valsartan capsules were given oral in the control group.After 4 weeks of treatment,the two groups compared the clinical symptoms of TCM before and after treatment and the levels of serum inflammatory factors(CRP,IL-6),immunoglobulin(Ig A,Ig G),complement(C3,C4)and urine routine(urine protein PRO,urine occult blood BLD)were statistically analyzed to evaluate their efficacy and safety.Results:1.In terms of efficacy: Among them,the number of effective people,24people(82.76%)in the experimental group and 18 people(64.29%)in the control group,For the Modern physic group,the TCM group was better,and the difference was statistically significant(P <0.05).2.In the aspect of clinical symptoms of TCM: there were statistical differences(P<0.05)in the experimental group in improving waist and kneesoreness,After treatment,five upset fever,yellow urine,edema,dizziness,tinnitus,dry mouth and throat,fatigue and weakness,and bitter mouth stickiness(P<0.05),and there was no statistical difference(P>0.05).In the comparison,there were statistical differences in waist and leg weakness in the control group(P<0.05),and there was no statistical difference(P>0.05)in the control group,and there were statistical differences in waist and knee soreness,five upset fever,puffiness,dizziness,tinnitus,and mouth and mouth stickiness(P<0.05),and there was no statistical difference(P>0.05).In the aspect of the total score,For the Modern physic group,the TCM group was better,and there was a statistical difference(P<0.05).3.In terms of Laboratory tests factors: Before and after treatment,within and between groups: no statistical differences in immunoglobulins and IL-6(P>0.05);no statistical differences before and after complement C3 treatment(P>0.05),no statistical differences before and after treatment in experimental groups(P>0.05),statistical differences before and after treatment in control groups(P<0.05),no statistical differences before and after treatment of complement C4(P>0.05),statistical differences before and after treatment in control groups and experimental groups(P<0.05),statistical differences before and after TREATMENT in CRP(P<0.05),and no statistical differences before and after treatment in control groups(P>0.05),there was a statistical difference before and after treatment in the experimental group(P<0.05).The total protein and albumin in the two groups before and after treatment were significantly improved;the urine protein and urine occult blood,urine trace protein and 24 h urine protein were reduced to varying degrees,and there were statistical differences(P<0.05);in the comparison between groups,the experimental group had a better effect than the control group,with a statistical difference(P<0.05).4.In terms of safety: in the treatment process,no adverse reactions occurred in the two groups,and no abnormalities occurred in liver function and kidney function.It is explained that the two groups have good security.Conclusions:Through this study,it was confirmed that the treatment of renal deficiency and damp heat type hennad purpura nephritis has a good effect,and the heat clearing benefit kidney can improve the symptoms of patients,inhibit the secretion of inflammatory factors and protein loss,promote protein absorption,and its inhibition of protein loss may be related to the repair of glomerular filtration membrane,in the treatment process,there is no serious adverse reaction,safe and effective.