Risk Factors For Microvascular Invasion Of Hepatitis B Virus-associated Hepatocellular Carcinoma

Objective: The purpose of this article is to study the risk factors of microvascular invasion of hepatitis B virus-associated primary liver cancer,and It provides scientific basis for preoperative diagnosis,treatment,prognosis evaluation and postoperative adjuvant therapy of liver cancer.Methods: A retrospective study of HBV-associated hepatocellular carcinoma(HCC)patients admitted from January 2018 to January 2022 in the HCC database of the First Hospital of China University of Science and Technology was conducted,and 890 patients were eventually collected according to the criteria for image inclusion and exclusion in the study,According to the criteria inclusion criteria and exclusion,grouped according to whether the patient’s the postoperative pathological results associated with MVI,Analyzed the factors leading to microvascular invasion of HBV-associated liver cancer,Analyzed the statistically significant single-variable risk factors,and performed a multivariate logistic regression analysis to identify independent risk factors for primary liver cancer,establishing a prediction model formula based on independent risk factors.By comparing the good fitting of the model with the pseudo-normal results,It is found that the model is superior to other methods in different degrees.Using the Receiver(Operative Characteristic,ROC)and Hosmer-Lemeshow trials,we were able to evaluate model differentiation and calibration test.Results: There were 890 patients with primary liver cancer,including 358 complicated by microvascular invasion,and univariate analysis was carried out according to the selected patients’ clinical symptoms,laboratory indexes and imaging indicators,According to the clinical symptoms of the selected patients,The results of univariate analysis showed that preoperative positive Hepatitis B virus e antigen(HBe Ag),Hepatitis B virus quantification(HBV-DNA),platelet-to-lymphocyte ratio(PLR),Y glutamine transdermase(GGT),prothrombin time(PT),mitochondrial aspartate aminotransferase(m AST),fibrinogen(Fg),alpha-fetoprotein(AFP),Maximum tumor diameter,degree of tumor cell differentiation,invasion of the liver envelope,antiviral therapy,and concomitant satellite foci were the relevant factors for MVI in HBV-related primary liver cancer(P<0.05),Further multivariate logistic regression analysis showed that the levels of AFP,m AST,Fg,hepatitis B virus quantification(HBV-DNA),tumor differentiation degree,invasion of the liver envelope,and satellite foci were independent risk factors for the incidence of MVI in HBV-related primary liver cancer(P<0.05).Conclusion:Preoperative elevation of AFP,m AST,Fg,HBV-DNA,invasion of the liver envelope,and satellite foci were independent risk factors for microvascular invasion in patients with HBV-associated primary liver cancer.These results provide clinicians with valuable reference information,build a prediction model based on the above independent risk factors for microvascular invasion of primary liver cancer,and formulate personalized surgical plans based on the probability values calculated on the basis of the prediction model combined with patient laboratory indicators and imaging indicators.