Meta-analysis Of The Correlation Between Serum Complement C1q,Fetuin-A Levels And Coronary Heart Disease

Objectives: 1.To systematically evaluate the correlation between serum complement C1q(C1q)levels and coronary artery disease.2.To systematically evaluate the correlation between serum fetal globulin A(Fetuin-A)levels and coronary artery disease.Methods: Computer searches were conducted on China Knowledge Network,Wanfang,Pub Med,Web of Science,Cochrane,Embase and other databases to collect published case-control studies on the association between serum complement C1 q and Fetuin-A levels and coronary artery disease at home and abroad until April 2022.Literature screening,data extraction,and methodological quality evaluation were performed independently by two researchers,and Meta-analysis,subgroup analysis,sensitivity analysis and publication bias analysis were performed using Rev Man 5.4 and Stata 16.0software.Results: 1.A total of 10 studies on the correlation between serum complement C1 q levels and coronary heart disease 10 studies met the inclusion criteria and a total of2011 subjects met the inclusion criteria(1240 in the case group and 771 in the control group).The results of the Meta-analysis showed no statistically significant difference between serum complement C1 q levels in the coronary heart disease group and the control group(SMD=-0.19,95% CI-0.85 to 0.48,P=0.58),and there was no correlation between serum complement C1 q levels and the development of coronary heart disease.By subgroup analysis of mean age,proportion of men,sample size,proportion of diabetes mellitus and serum complement C1 q assay in the included population,the results of each subgroup analysis showed that the difference between serum complement C1 q levels in the coronary artery disease group and the control group remained statistically insignificant and there was no correlation between serum complement C1 q levels and the development of coronary artery disease.Sensitivity analysis and publication risk bias analysis showed that the results of the included studies were stable and reliable.2.A total of 21 studies on the correlation between serum Fetuin-A levels and coronary heart disease 23 studies met the inclusion criteria and a total of 6210 subjects met the inclusion criteria(2506 in the case group and 3704 in the control group).Meta-analysis showed no statistically significant difference between serum Fetuin-A levels in the coronary artery disease group and the control group(SMD=-0.25,95% CI-0.62 to 0.12,P=0.19),and there was no correlation between serum Fetuin-A levels and the development of coronary artery disease.The results of the subgroup analysis of the included population from different regions showed that low serum Fetuin-A levels were associated with the development of coronary heart disease in non-Asian populations(SMD=-0.88,95% CI-1.47 to-0.29,P=0.003).The results of the male predominance subgroup analysis showed that low serum Fetuin-A levels were associated with the development of coronary heart disease in <60% of men(SMD=-0.61,95% CI-1.17 to-0.05,P=0.03).The results of the sample size subgroup analysis showed that high serum Fetuin-A levels were associated with the development of coronary heart disease in people with a sample size ≥200(SMD=0.44,95% CI 0.12 to 0.76,P=0.007).The results of the subgroup analysis showed that low serum Fetuin-A levels were associated with the development of coronary heart disease in those with <50% diabetes(SMD=-0.48,95% CI-0.88 to-0.08,P=0.02);high serum Fetuin-A levels were associated with the development of coronary heart disease in those with ≥50% diabetes(SMD= 1.48,95% CI 0.68 to 2.27,P=0.0003).However,in Asian populations,Stable angina pectoris(SAP),Unstable angina pectoris(UAP),Myocardial infarction(MI),mean age(<60 and≥60 years),male predominance ≥60%,sample size <200 population,and subgroup analysis showed that serum Fetuin-A levels did not correlate with the development of coronary heart disease.Sensitivity analysis and publication risk bias analysis showed that the results of the included studies were stable and reliable.Conclusion: 1.Meta-analysis showed no correlation between serum complement C1 q levels and coronary artery disease.2.Meta-analysis showed no correlation between serum Fetuin-A levels and coronary heart disease.However,subgroup analyses showed a correlation between serum FetuinA levels and coronary heart disease in non-Asian populations,in <60% of men,in sample sizes ≥200,and in different percentages of people with diabetes.