| Objective : To observe the therapeutic efficacy of strengthening BEN and liver, eliminating toxicant and activating blood circulation principles for the mixture Tanggankang effect of the diabetes -induced liver injury and its mechanism.Method : According to the theory of TCM and tutor's clinical experience we thought the diabetes-induced liver injury is "bad deficiency, liver disorders reached, toxicant and blood circulation unity," the features of the disease. "Jianpi Yiqi treat this tune liver detoxification and activating blood circulation treat the symptoms" of political will, organize Gankang Compatible sugar mixture. and the Clinical and Experimental Research. 1. Clinical research : the light of the diagnostic criteria for diabetes-induced liver injury, will be confirmed 60 cases of liver injury in diabetic patients were randomly divided into treatment and control groups, 30 patients in each group, Mixture of Tanggankang which treatment group (each 50ml, two times a day ). A control group was given the Jangtangjia tablets (each 6 slices, three times a day), were treated for two months. Treatment of patients with signs and symptoms were observed before and after the changes, and liver function and liver ultrasound. 2 hours postprandial and fasting insulin, fasting and 2-hour postprandial blood glucose, glycosylated hemoglobin, serum lipids, and changes in blood flow and other indicators. 2. Experimental Study : CCl4-induced liver injury through the establishment of animal models of chronic and STZ-diabetic rat model high-fat diet observed consolidate regulation of CCl4-induced hepatic detoxification Huoxue chronic liver injury induced liver function, Superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor (TNF). interleukin-6 (IL-6) and the impact of STZ-diabetic rats high-fat diet, serum lipids, changes in blood flow and insulin-related indicators, and statistical analysis for evaluating the effect.Results : Firstly,clinical study found that Sugar Mixture will not only effectively improve the liver of diabetic patients with symptoms and signs of liver damage. And it can be significantly improved in patients with liver function and fatty liver, insulin resistance also improved significantly. increase the role of insulin sensitivity, and can improve blood glucose, HbA1c, lipid and blood flow changes Groups significantly better than glibencla- mide.Secondly,The experimental results show that Sugar Mixture liver NBD not only significantly improved as a result of chronic liver injury induced by abnormal liver function. SOD and MDA as well as TNF-αand IL-6 levels of STZ high fat and diabetic rats, blood lipids, changes in blood flow, but also significantly improved insulin levels, significantly better than hypo- glycemic Groups.Conclusion : Jianpi Yiqi main, and transferred to the liver detoxification. Method of Strengthening BEN and liver, eliminating toxicant and activating blood circulation is integral to the effective prevention and treatment of diabetic sugar mixture Gankang liver injury. We should thoroughly study its mechanism.
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