The Effects Of Shenghuazhixueyin On Progesterone Receptor And Apoptosis Gene In Rats' Decidua After Medical Abortion

Objective:To investigate Shenghuazhixueyin's effects and the function mechanism to decidua's morpholog,progesterone receptor(PR),the factors of apoptosis such as Fas,FasL and apoptosis inhabitory gene Bcl-2 and it's mRNA after the rats' medical abortion.Methods:Divide forty pregnant rats randomly into the normal group,the model group,yimucao group and Shenghuazhixueyin group,then observe the morpholog under Optical Microscope.Then detect the expression of PR and Fas,FasL by the immunohistochemical method and detect the expression of Bcl-2 and it's mRNA by the method of immunohistochemical and in situ hybridization.Results:The normal group shows normal decidual cell with integrate structure;the model group shows patchy degeneration,necrosis;Yimucao group shows that decidual is loose and broken;Shenghuazhixueyin group shows normal endometrium.Shenghuazhixueyin can remarkably raise the expression of Fas,FasL and decrease PR,Bcl-2 and it's mRNA's expression in womb decidua.Comparing with the normal group,the model group and yimucao group,there are significant differences(p＜0.05). Shenghuazhixueyin group has a better curative effect than yimucao group.Conclusion:Shenghuazhixueyin can remarkably reduce the amount of decidual cells and make decidua flake quickly by the way of increasing the expression of Fas,FasL and decreasing the expression of PR,Bcl-2 and it's mRNA.It will accelerate the endometrium regeneration and obviously reduce the colporrhagia time and reach the purpose of hematischesis.