| Objective We explore the prevalence of metabolic syndrome (MS) and obesity in a cohort of Wuming community of Guangxi province, and compare the changes of risk factors about MS during 1998 to 2008. We also investigate the association and relationship between MS and aggregation of risk factors in this community. And we put forward some prevention strategies for this community.Methods 1000 subjects (age 35～60 years) for the cohort study was carried out in a population from Wumao and Tuanjie community of Wuming cohort that was one of the fifteen groups of year 1998 China Multi-center Cooperative Cardiovascular Epidemiology Study Cohort (national "9·5" cohort). And the dates about cardiovascular disease risk factors which was collected in 1998 was used as baseline material. The subjects were divided into 5 groups by ages (group 1:35～39 years old, group 2:40～44 years old, group 3:45～49 years old, group 4:50～54 years old, group 5:55～60 years old).A follow-up survey was conducted for 1000 subjects of the Wuming cohort in 2008. We investigated 5 risk factors (waistline, blood pressure, fasting plasma glucose, triglyceride, high density lipoprotein cholesterol). Metabolic syndrome was defined according to the International Diabetes Federation (IDF) consensus worldwide definition in 2005.Results (1)The crude prevalence of metabolic syndrome was 13.6%(n=737) The age-standardized prevalence of metabolic syndrome was 13.7%(male was 7.1% and female was 19.8%) and the overall prevalence of obesity was 3.8% (1.4% in men,5.7% in women). (2)There were significant differences between MS patients and non-MS subjects including body weight, waist circumference, BMI, systolic pressure, diastolic pressure, TG, FBG, HDL-C (P<0.001). (3)Logistic regression analyses revealed that waistline (OR= 1.201, P<0.001), blood pressure (OR=4.750, P<0.001) and fasting plasma glucose (OR=1.016, P<0.01) were positive associated with MS, and HDL-C (OR=0.956, P<0.001) is negative associated with MS at this community. (4)From 1998 to 2008, the increase of waistline and heart rate in female were significantly higher than male (P<0.05).(5)Between 10 years, BMI had markedly increased in these groups of male (group 1,2,3,4) and female (group 1,2,3,4) (P<0.05).Waistline, systolic blood pressure, diastolic blood pressure and fasting plasma glucose both had significantly increased for every male and female age group (P<0.01). TG was significantly increased in these groups of male (group 3,4,5) and all female groups. HDL-C had significantly difference in these groups of male (group 2,3) and female (group 1,2).(6)The risk factor aggregated ratio of all subjects was significantly increasing from 1998 to 2008 (P<0.001)Conclusion The result of prevalence of metabolic syndrome in this study was similar with some MS prevalence survey in nation. Between 10 years, waistline, BMI, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and TG of subjects of Wuming community cohort had increased. waistline, blood pressure waistline, fasting plasma glucose abnormal were all independent risk factors associated with MS, and HDL-C is negatively associated with MS at Wuming community. To explore the underlying pathophysiologic mechanisms of risk factor aggregation and effection in MS subjects by cohort study is of utmost importance in guiding MS community control.
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