The Influence Of Dexmedetomidine With General Anesthesia Effect Undergoing Vocal Cord Polyps Extirpation

Objective To observe the influence of dexmedetomidine with general anesthesia in patients undergoing vocal cord polyps extirpation.Methods72patients undegoing vocal cord polyps extirpation were randomly divided into three groups with24cases each group:patients were intravenously injected dexmedetomidine1μg/kg (group A and B) or0.9%normal saline0.25ml/kg (group C) with constant speed befor induction of anesthesia10min, then group A to continuous infusion dexmedetomidine0.5μg/kg·h and group B and C to continuous infusion0.9%normal saline0.125ml/kg·h until the end of surgery. All the other induction and maintenance drugs were administered in the same way in the three groups. The hemodynamics were detected basic value(T0), before induction(T1), before intubation(T2), intubating(T3), at5min after intubation(T4), suspensing laryngoscopy(T5), the end of surgery(T6), aspiration of sputum(T7), extubating(T8), at5min after extubation(T9). Propofol consumption, anesthesia recovery and side effects were recorded as well. Results the SBP, DBP, HR of T0, compared T1with higher in group A and B (P<0.05), compared T3, T7, T8, T9with significantly higher in group C(P <0.05), three groups were significantly decreased at T2(P<0.05); the SBP, DBP, HR of group A and B compared group C with significantly lower in the T3, T7, T8, T9,(P<0.05), the difference between the group A and B was barely statistically significant (P>0.05); the SBP, DBP, HR of three groups patients were not statistically significant (P<0.05).The consumption of Propofol and Remifenfanil was obviously reduced comparing the group A and B with the group C (P<0.05), the difference between the group A and B was barely statistically significant (P>0.05). Incidences of pharynx ache and restlessness of three groups of patients were statistically significant(P<0.05). There was no significant difference in the recovery time from anesthesia between there groups(P>0.05).Conclusion dexmedetomidine can reduce perioperative stress response, anesthetics consumption and the incidence of side effects without respiratory depression.