Expression And Clinical Significance Of CD147,MCT1and MCT4in Cervical Lesions

ObjectiveCervical lesions include cervical intraepithelial neoplasia(CIN) and cervical cancer. The evolution of CIN progression to cervical cancer needs5-10years. Accurate identification of CIN patients who are high-risk groups developted to cervical cancer is the foundation and prerequisite for proper treatment. Therefore, in recent years the molecular biological indicators in the process from CIN to cervical cancer has become a hotspot research area. This study will explore the effect of CD147, MCT1and MCT4in the progression from CIN to cervical cancer and judge the feasibility of them to be high-risk objective indexes in the development from CIN to cervical cancer.MethodsImmunohistochemical SP method was used to detect the expression of CD147, MCT1and MCT4in normal cervical tissue, CIN I-III and cervical cancer.Results1. The expression of CD147in normal cervix group is lower than that in CIN group(x2=9.458, P=0.002); the expression of CD147in CIN group is lower than that in cervical cancer group(x2=20.909,P=0.000); expression of CD147in cervical cancer group was significantly higher than that in normal cervix group(x2=27.668, P=0.000).In patients with different degree of CIN, the expression of CD147in CIN1group was lower than that in CIN2-3group(x2=4.907, P=0.027).In patients with cervical cancer, the expression of CD147in age less than or equal to35years old group was lower than that in the age more than35years old group(x2=5.436, P=0.020). The expression of CD147in Clinical stage Ⅰ-Ⅱ group was lower than that in clinical stage Ⅲ-Ⅳ group(x2=3.950, P=0.047). The expression of CD147in well-differentiated tumor group was lower than that in middle-low differentiation cancer group (x2=5.606, P=0.018). The expression of CD147was relevant to the age, the clinical stage and the tumor differentiation degree.2. The expression of MCT1in normal cervix group is lower than that in CIN group(x2=9.759, P=0.002); the expression of MCT1in CIN group is lower than that in cervical cancer group(x2=10.733, P=0.001); expression of MCT1in cervical cancer group was significantly higher than that in normal cervix group(x2=22.255, P=0.000).In patients with different degree of CIN, the expression of MCT1in CIN1group was lower than that in CIN2-3group(x2=5.211, P=0.022).In patients with cervical cancer, the expression of MCT1in age less than or equal to35years old group was lower than that in the age more than35years old group (x2=7.008, P=0.008). The expression of MCT1in Clinical stage Ⅰ-Ⅱ group was lower than that in clinical stage Ⅲ-Ⅳgroup(x2=6.566, P=0.010). The expression of MCT1in well-differentiated tumor group was lower than that in middle-low differentiation cancer group (x2=6.791, P=0.009). The expression of MCT1was relevant to the age, the clinical stage and the tumor differentiation degree.3. The expression of MCT4in normal cervix group is lower than that in CIN group(x2=4.800,P=0.028); the expression of MCT4in CIN group is lower than that in cervical cancer group (x2=21.179, P=0.000); expression of MCT4in cervical cancer group was significantly higher than that in normal cervix group(x2=23.566, P=0.000).In patients with different degree of CIN, the expression of MCT4in CINl group was lower than that in CIN2-3group(x2=5.228, P=0.022).In patients with cervical cancer, the expression of MCT4in age less than or equal to35years old group was lower than that in the age more than35years old group(x2=11.579, P=0.001). The expression of MCT4in Clinical stage Ⅰ-Ⅱ group was lower than that in clinical stage Ⅲ-Ⅳ group, but no statistically significant difference between the two groups (x2=1.407, P=0.236). The expression of MCT4in well-differentiated tumor group was lower than that in middle-low differentiation cancer group (x2=10.225, P=0.001). The expression of MCT4was relevant to the age and the tumor differentiation degree and wasn’t related to the clinical stage.4. Positive correlation was found between CD147and MCTl in tissues of cervical lesion (r=0.641, P=0.002); Positive correlation was also found between CD147and MCT4in tissues of cervical lesion (r=0.658, P=0.001); Significant positive correlation was found between MCTl and MCT4in tissues of cervical lesion too (r=0.676, P=0.001)。Conclusion 1. CD147, MCT1and MCT4had cooperative interaction and play important roles in the development of CIN and cervical carcinoma.2. CD147, MCT1and MCT4can be judge as the risk objective indexes in progression from CIN to cervical cancer. For the high expression of CD147, MCT1and MCT4high level or low level of CIN patients should be given active treatment and following-up.