The Clinical Observation On The Treatment Of Damp-heat Ulcerative Colitis With Jiawei Shaoyao Decoction Combined With Enema

Objective:We treat the patients of ulcerative colitis who belong to the active and damp-heat type with the oral Jiawei Shaoyao Decoction and the enema of self-made decoction combined with the regular treatment of western medicine in this study. Then we aim to provide the theoretical basis and practical dates for the comprehensive therapy of ulcerative colitis by the traditional Chinese and western medicine, through the observation of its clinical effects and the influence on the inflammatory indexes such as ESR(erythrocyte sedimentation rate)、CRP(C-reactive protein) and PLT(platelet count).Methods:In this study,63definite patients of ulcerative colitis who belong to the active and damp-heat type are randomly divided into treatment group which contains32cases and control group which includes31cases, according to the order of seeing a doctor. On the basis of general treatment, the control group is given the oral Mesalazine sustained-release Granules (Etiasa),1.0gram each time,four times a day. While the treatment group is given the same therapy as the control group and the oral Jiawei Shaoyao Decoction combined with the enema of self-made decoction. The course of treatment is28days. We statistically analyzed the results of the two groups according to the pre-&post-treatment changes of the main symptoms、mucosal appearance under colonoscopy and the inflammatory indexes such as ESR, CRP and PLT. And then give the treatment a comprehensive evaluation on the clinical efficacy and safety.Results:1. After the treatment, compared with the pre-treatment, the total score of the TCM symptoms of the two groups is significantly decreased. And that of treatment goup is better than that of control group (P<0.01); The marked improvement rates of the main TCM symptoms of the two groups are93.75%and51.61%respectively. There is significantly difference in statistics (P<0.01) and the rate of treatment goup is better than that of control group.2. In improving the main TCM symptoms such as abdominal pain, tenesmus, it’s better in the treatment group than that in the control group (P<0.05).While there is no obvious difference in releasing the diarrhea and pus and blood stool.3. After the treatment, compared with the pre-treatment,the level of ESR in the two groups and the level of PLT in the treatment group are significantly decreased.And in lowering the level of ESR,the treatment group is better than the control group (P<0.05).In improving the level of PLT, there is no statistical difference between the two groups.4. During the period of treatment, there is no obvious side effect in the two groups.Conclusion:The clinical effect of the comprehensive therapy which contains the oral Jiawei Shaoyao Decoction and the enema of self-made decoction combined with general treatment of western medicine in treating the damp-heat ulcerative colitis is satisfactory, and it is better than that of western medicine alone. It is able to effectively improve the symptoms such as abdominal pain, tenesmus and deceline the level of the inflammatory indexes as ESR.And it is a safe and effective therapy.