Correlation Between OX-LDL And Its Ratio And Poor Functional Prognosis Of Acute Cerebral Infarction

Objectives The plasma ox-LDL levels in 3627 patients with acute cerebral infarction were measured by enzyme-linked immunosorbent assay.Calculate the ratio of oxLDL/high-density lipoprotein(HDL)and ox-LDL/low-density lipoprotein(LDL),and explore the relationship between ox-LDL and its ratio and acute cerebral infarction and brain Relationship between poor prognosis of infarct subtypes.Methods In 3,634 patients admitted to the study of oxidative stress in patients with acute ischemic stroke(Study on Oxidative Stress in Subjects with Academic Ischemic Stroke,SOS-Stroke),all patients were classified into five different subtypes according to TOAST criteria.The relationship between ox-LDL levels and the clinical outcome of stroke deaths and dysfunctions(improved Rankin scale score 3-5)was analyzed by multivariate regression analysis.Results 1 Among the 3627 patients included in the study,the average age was(64.01±11.97)years,and the number of women was 1282(34.33%).The average plasma ox-LDL concentration was(56.76±20.95)μg/dl.According to the plasma ox-LDL quartiles,subjects were divided into 4 groups: quartile 1(Q1),<47.97 μg/dl;quartile 2(Q2),48.03 to 62.67 μg/dl;quartiles 3(Q3),62.75 to 70.10 μg/dl;quartiles 4(Q4),≥ 70.19 μg/dl.The average ox-LDL concentrations in these groups were 25.88±14.87,57.17±4.04,66.30±2.13,and 77.64±5.76 μg/dl,respectively;the subjects were divided into 4 groups according to the plasma ox-LDL/HDL quartiles levels.: Q1,<37.43;Q2,37.44 to 53.53;Q3,53.59 to 68.67;Q4,≥ 68.72.Ox-LDL/HDL were 20.67±11.73,46.30±4.44,60.82±4.33,and 86.65±24.02,respectively;subjects were divided into four groups based on plasma ox-LDL/LDL quartiles: Q1,<15.13;Q2,15.14 to 21.10;Q3,21.11 to 28.21;Q4,≥ 28.25.Ox-LDL/LDL were 8.65±4.65,18.27±1.69,24.35±2.07 and 38.42±12.55,respectively.2 Among the 3627 patients included in this study,285(7.86%)died at the 1-year follow-up and 1002 patients(27.63%)Functional outcomes were poor(modified Rankin Scale scored 3-5).Multivariate analysis of Ox-LDL,ox-LDL/HDL,ox-LDL/LDL and poor functional outcomes and death outcomes in patients with cerebral infarction revealed that ox-LDL,ox-LDL/HDL,and high-quartile arrays(four)The quantile 4)risk of adverse outcomes and death in patients with cerebral infarction in the lower quartile was higher,even adjusting for potential confounders.The blood glucose,diabetes history,history of hypertension,history of hyperlipidemia,history of atrial fibrillation,history of stroke,and scores of Stroke Scales of the National Institutes of Health were still relevant(P < 0.05).3 In the poor-functioning prognostic group,high ox-LDL levels were only associated with the LAA subgroup and the SAO subgroup positive correlation(P<0.05);ox-LDL in death outcome group,ox-LDL level LAA subgroup and SAO subgroup was positively correlated(P<0.05).In the poor-functioning prognostic group,high oxLDL/HDL levels were associated with LAA subgroups and SAO subgroups.Positive correlation(P<0.05);ox-LDL/HDL in death outcome group,ox-LDL/HDL level with LAA subgroup and SAO subgroupwas positively correlated(P<0.05);high ox-LDL/LDL levels in the poor-function prognosis group were only associated with the SAO subgroup was positively correlated(P<0.05).In the death outcome group,there was no correlation between ox-LDL/LDL levels and each cerebral infarction subgroup(P>0.05).Conclusions 1 High plasma ox-LDL and ox-LDL/HDL levels in patients with acute cerebral infarction are independent risk factors for poor prognosis of cerebral infarction;high ox-LDL/LDL levels are independent risk factors for poor prognosis of cerebral infarction and have no effect on death outcomes.2 High-level ox-LDL and ox-LDL/HDL increased the risk of poor prognosis in the LAA and SAO cerebral infarction groups,but not in the cardiac embolism and other stroke subtypes.3 The high level of Ox-LDL/LDL is only a risk factor for the functional prognosis of SAO type cerebral infarction.In the death outcome group,the ox-LDL/LDL levels had no effect on the prognosis of each cerebral infarction subgroup.