Professor Ni Cheng's Theory Inheritance And Data Mining Research On The Treatment Of Allergic Rhinitis By Body Differentiation

Background:In recent years,with the improvement of the level of social industrialization,changes in people’s lifestyles and environments,the incidence of allergic rhinitis has gradually increased at home and abroad.Allergic rhinitis is a non-infectious inflammatory disease of the nasal mucosa released by IgE-mediated mediators of atopic individuals after exposure to allergens,and involving a variety of immunocompetent cells and cytokines to prevent persistent or intermittent nasal congestion,Nose itching,frequent sneezing,and runny nose are not only the main manifestations,but also have the characteristics of easy recurrence and difficult to cure,which seriously affects people’s health,quality of life,work and learning efficiency.At present,there are many difficulties in the treatment of allergic rhinitis:① There are many types of allergens in real life,and it is difficult to completely avoid contact with allergens;② There are many ways for allergens to invade the human body,and it is difficult to respond one by one;③clinically Most of them are symptomatic or syndrome-based treatment,and the focus of treatment is mostly on the morbid state.It is easy to relapse after treatment,and the non-morbid state is often ignored.Therefore,it is necessary to find a better treatment plan to achieve the advancement of prevention and treatment.Academician Wang Qi is the founder of TCM Physiology and is good at treating various allergic diseases.Professor Ni Cheng,as his academic heir,inherits Professor Wang Qi’s academic thoughts on body-discrimination and principal disease treatment for allergic rhinitis.Purpose:①Summarize the inheritance characteristics of Professor Ni Cheng and his tutor in the treatment of allergic rhinitis,explore the inheritance and reproducibility of the clinical experience of famous old Chinese medicine,in order to sustain the inheritance of the clinical experience of famous old Chinese medicine.②Using modern data mining technology,mining the prescription rules of Professor Ni Cheng’s body discrimination-discrimination treatment of allergic rhinitis,providing new ideas and new methods for the prevention and treatment of allergic rhinitis,and further confirming the inheritance and experience of famous and experienced Repetitive questions.Method:1.Professor Ni Cheng’s theoretical inheritance research on treatment of allergic rhinitis By consulting relevant literature,regularly studying with the teacher’s outpatient clinic,and listening to the lecturer,etc,academician Wang Qi’s academic thoughts and clinical experience in the treatment of allergic rhinitis were summarized,and the inheritance of Professor Ni Cheng and his tutor in the treatment of allergic rhinitis was summarized and analyzed features.2.Professor Ni Cheng’s data mining research on treatment of allergic rhinitisCollected the clinical medical records of Professor Ni Cheng from June 2008 to October 2019 in the outpatient department of the Chinese Medicine Hall of Beijing University of Chinese Medicine for the treatment of allergic rhinitis.According to the inclusion criteria,the medical records of 131 patients were finally included,including The patient’s age,gender,physique,disease,symptoms and other information as well as 217 first prescription medication information for the first and second visits.Use Microsoft Excel 2016 to convert the electronic version of the paper medical case,and normalize and extract the relevant data in it,then enter it into the corresponding module of the Traditional Chinese Medicine Heritage Support Platform(V2.5),using frequency analysis,association rules,and entropy clustering Methods and other mining techniques,excavating Professor Ni Cheng’s prescription-medication-diagnosis and treatment model for the treatment of allergic rhinitis,summed up the inheritance of prescription medicines for the treatment of allergic rhinitis by Professor Ni Cheng and his tutor.Result:In the theoretical inheritance study of Professor Ni Cheng’s treatment of allergic rhinitis by body identification,the academic thought of Professor Wang Qi’s treatment of allergic rhinitis is the main disease in the onset period,and the theory of treatment in the remission period is differentiated;On the understanding of the onset of rhinitis,Professor Ni Cheng summed up the concept of the occurrence of special constitutional intolerance of different qi;on the understanding of the pathogenesis,Professor Ni Cheng inherited the incompatibility of Professor Wang Qi,and the invasion of different qi caused the fever.On the basis of the understanding of the pathogenesis of nasal rhinorrhea,it is further proposed that the underlying heat in the lungs can affect the blood distribution and cause the pathology of blood fever,qingxuanfu fever,sanxuetongqiao,desensitization and cooling blood,Qingxuanfu fever.In the data mining study of Professor Ni Cheng’s body identification and disease treatment for allergic rhinitis,the constitutional type statistics showed that there were 95 cases of allergic rhinitis patients with special constitution and 36 cases with other constitutions.Among the cumulated constitutions,the traits with both traits and yang deficiency are the most,followed by the traits with traits and qi deficiency.The statistics of the frequency of constitutional medicines show that the commonly used medicaments for special constitution are cicada,ebony,lily,ganoderma lucidum,madder,windproof,Shouwu vine and comfrey.Among the cumulant constitutions,the medicaments with special constitution and yang deficiency constitution are cicada,ebony,twig,white peony,lily,ganoderma lucidum,rubia,and comfrey;the medicaments with special constitution and qi deficiency constitution are cicada,Ebony,astragalus,lily,and ganoderma;the special qualitative and moist heat-regulating drugs are cicada,ebony,ganoderma,lily,scutellaria,Shouwuteng,talc,Yinchen,and Coptis.Based on the association rule-based analysis of specific constitutional medicines,the support degree is 56 and the confidence level is 0.8.The high-frequency drug combination is ume-cicada>ebony-lily>lily-cicada-decay>ebony-lily-cicada>ebony-lingzhi>Cicada-lingzhi>Ebony-Cicada slump-Ganoderma lucidum>Ebony-cricket herb>Cicada slump-Cinnamomum>Ume-Cicada slump-Celiac,etc.;The drug rules with higher relevance are ebony->Cicada slump,Ganoderma lucidum->Prunus sibiricum,Rubia sibiricus->Prunus sibiricus,Lily,Rubia->Black plum,cicada slough,Ganoderma lucidum->black plum,lily,rubia->black plum,cicada slough,etc;core body-adjusting medicines with special physique are cicada slump,black plum,lily,ganoderma lucidum,and rubia.In the study of disease identification drugs,after statistics on the types of diseases and the frequency of their use,the commonly used drugs for allergic rhinitis are cicada,ebony,lily,Xinyi,baicalin,licorice,gypsum,silkworm,ephedra,and ganoderma.In the treatment of allergic rhinitis combined with other diseases,combined with cough variant asthma,commonly used Houpu Mahuang Decoction is used for addition and subtraction treatment,such as scutellaria,licorice,magnolia,ephedra,almond,scape,pepper,etc;gypsum,urticaria commonly used,Medicines such as Xinyi,Rubia,Wild Grass,Peony Bark,Buffalo Horn,Nepeta and other drugs;combined with eczema commonly used Ephedra Lianchi Chixiaodou Decoction and Rhizoma Dihuang Decoction,such as buffalo horn,gypsum,peony bark,licorice,ephedra,Sophora Coptis chinensis,duckweed,etc;combined treatment of insomnia commonly used Wendan soup,Jiaotai pill,Suanzaoren decoction,such as lily,jujube kernel,Prunella vulgaris,cinnamon,Coptis chinensis,Zhuru,Zhishi,Pinellia,etc.Based on the association rules,the prescription medications for allergic rhinitis were analyzed.The degree of support was 62,the confidence was 0.8,and the combination of high-frequency drugs was ume-cicada>ume-lily>lily-cicada>ume-lily-cicada>ume-Xinyi>Xinyi-Cicada slough Wume-Xinyi-Cicada slough>Lily-Xinyi>Wume-lily-Xinyi>Lily-Xinyi-Cicada slaughter,etc;The drug rules with higher relevance are Cicada slough->Wume,Scutellaria->Wume,Lily->Wume,Bombyx mori->ebony,etc;the core drugs for allergic rhinitis are cicada,ebony,lily,skullcap,gypsum,ephedra,silkworm,xinyi,licorice.Based on the entropy clustering method,the prescription rules of allergic rhinitis were analyzed,and the core drug combinations were mulberry-wind-wildweed-ephedra,gypsum-poria-madder-ephedra,poria-mulberry-madder-ephedra,gypsum-Windproofing-Rubia-ephedra,Polyporus-Licorice-Shouwuteng,etc;the new drug combination is Poria-Sangbaipi-Rubia-ephedra-windproof,gypsum-Poria-Rubia-ephedra-windproof and so on.After counting the frequency of disease medication,the drugs used for the treatment of allergic rhinitis 50 times or more are cicada,ebony,lily,Xinyi,baicalin,licorice,gypsum,silkworm,ephedra,ganoderma lucidum,madder,mulberry,Chuanxiong,windproof,angelica.In the treatment of allergic rhinitis combined with other diseases,cough variant asthma is commonly used in Magnolia officinalis,gypsum,ephedra,Xinyi,Tinglizi,Jiamu,Dilong,almonds,etc;gypsum,Xinyi,Scutellaria baicalensis,Rubia,Licorice,ephedra,angelica,peony bark,buffalo horn,wild wild grass and other drugs;combined eczema commonly used Xinyi,gypsum,peony bark,licorice,ephedra,buffalo horn,Coptis chinensis,duckweed,etc;combined insomnia commonly used lily,Chuanxiong,Prunella vulgaris,Xinyi,jujube kernel,Poria,Pinellia,Coptis chinensis,etc.Based on the association rules,the prescription medications for allergic rhinitis were analyzed.The degree of support was 62,the confidence was 0.8,and the combination of high-frequency drugs was ume-cicada>ume-lily>lily-cicada>ume-lily-cicada>ume_Xinyi>Xinyi-Cicada slough>Wume-Xinyi-Cicada slough>Lily-Xinyi>Wume-lily-Xinyi>Lily-Xinyi-Cicada slaughter,etc;The drug rules with higher relevance are Cicada slough->Wume,Scutellaria->Wume,Lily->Wume,Bombyx mori->ebony,etc;the core medicines for the treatment of allergic rhinitis are ebony,cicada,lily,ganoderma lucidum,rubia,baicalin,silkworm,gypsum,ephedra,xinyi,mulberry,and licorice.Based on the entropy clustering method,the prescription rules of allergic rhinitis were analyzed,and the strong correlation drugs were found to have Rubia-Pangolin,Ephedra-Ganoderma lucidum,Sangbaipi-Astragalus;the core drug combination was Sangbaipi-Fangfeng-Chencao-Ephedra,Gypsum-Poria-Rubia-ephedra,Poria-Mulberry-Rubia-ephedra,etc;the new drug combination is Poria-Mulberry-Rubia-ephedra-wind,gypsum-Poria-Rubia-ephedra-wind.Statistics of symptoms appearing in the medical records,the most frequent occurrences are sneezing,stuffy nose,itchy nose,runny nose,itchy eyes,cough,asthma,sputum,cold air sensitivity,itchy throat,etc.After analyzing the symptoms based on the association rules,the support degree is 25 and the confidence level is 0.8.The symptom rules with higher association degrees are nasal congestion,sneezing,and thin and greasy fur->pulse floating and slipping.Based on the association rules,after the network analysis of the four major symptoms(sneeze,nasal congestion,nasal itching,runny nose)and drugs,the symptomatic drugs for nasal congestion and sneezing are mainly Xinyi,Chuanxiong,Angelica dahurica;the symptomatic drugs for nasal itching are stiff silkworm,windproof Mainly;symptomatic drugs for runny nose are Sangbaipi,Poria and Poria.In conclusionProfessor Wang Qi believes that one disease must have the main prescription.The main prescription for the treatment of allergic rhinitis during the attack is mainly based on the main prescription for the disease-causing pathogenesis,according to the physical constitution,comorbidities and syndromes.So as to add or subtract treatment.Professor Wang Qi’s treatment of allergic rhinitis during the remission period is mainly based on differentiation of body treatment,focusing on conditioning special constitution.Professor Ni Cheng and his tutor’s theoretical inheritance characteristics for the treatment of allergic rhinitis:On the understanding of the onset of allergic rhinitis,Professor Ni Cheng summarized the concept of the occurrence of special insufficiency of different gas;on the understanding of pathogenesis,Professor Ni Cheng On the basis of inheriting the understanding of Professor Wang Qi’s impatience,foreign gas invasion,triggering fever,and the pathogenesis of dry nose rhinitis,he further proposed that the lung fever can affect blood distribution and cause pathology of blood fever;In terms of thinking,Professor Ni Cheng’s treatment of allergic rhinitis is mainly based on desensitization and cooling blood,clearing Xuanfu fever,and dispelling evil spirits,and attaches importance to desensitization cooling blood and clearing xuanfu fever.Through the data mining of Professor Ni Cheng’s treatment of allergic rhinitis,summarize the rules of prescription medication for allergic rhinitis in the body-diagnosis diagnosis and treatment mode,and further summarize the allergic rhinitis prescriptions of Professor Ni Cheng and his instructor Inheritance of medication.Professor Ni Cheng’s main drugs for allergic rhinitis are ebony,cicada,lily,ganoderma,rubia,comfrey,scutellaria,silkworm,gypsum,ephedra,windproof,Xinyi,Chuanxiong,Sangbaipi,which is treated by Professor Wang Qi The main prescription of allergic rhinitis-"Demin Zhi Zhi Tang",with the addition of Rubia,Lithospermum to clear the heat and cool the blood to desensitize and adjust the specific constitution;for the allergic rhinitis outflow of different gases,the hot nose For the pathogenesis of the problem,Professor Ni Cheng uses cicada slough and stiff silkworm to lightly dissipate heat.A small dose of ephedra can disperse evil Xuantong nasal qiao,and can be mixed with Xinsan cold gypsum to enhance the power of clearing Xuanfu;The main symptoms of rhinitis,Professor Ni Cheng uses Chuanxiong huoxue tongqiao to treat nasal congestion and sneezing,Sang Baipi clears lung fever,dilutes diuretic water,helps lung Xuanhuajin fluid to stop the runnyIn summary,through Professor Ni Cheng’s theoretical inheritance study on the treatment of allergic rhinitis by body identification and disease differentiation,he summarizes the inherited characteristics of Professor Ni Cheng and his tutor’s understanding of the onset,pathogenesis,and treatment of allergic rhinitis,proving the famous old Chinese medicine The clinical experience is inherited and reproducible,which is conducive to the inheritance and development of the experience of famous and old Chinese medicine.Through the data mining of Professor Ni Cheng’s clinical diagnosis and treatment of allergic rhinitis,summarize the rules of prescription medication under the diagnosis and treatment model,and then summarize the allergic rhinitis by Professor Ni Cheng and his instructor The inheritance characteristics of prescription medications provide new ideas and new methods for the prevention and treatment of allergic rhinitis,and at the same time further confirm that the experience of famous traditional Chinese medicine is inherited and repeatable.Professor Ni Cheng chooses different drugs for different types of allergic rhinitis,combined diseases,and combined symptoms under the body-diabetes diagnosis and treatment model.While treating the disease,he pays attention to the conditioning of the physical soil and the prevention and treatment of allergic rhinitis.Moving forward is of great significance.