Clinical Observation Of Tongmai Jieyu Decoction In The Treatment Of Stable Angina Pectoris Of Coronary Heart Disease With Heart-liver Stagnation Type

Objectives Through the clinical observation of Tongmai Jieyu Decoction in the treatment of stable angina pectoris of coronary heart disease with heart-liver stagnation type,to explore its clinical effect,in order to provide basis for further research and application.Methods 72 patients with stable angina pectoris of coronary heart disease with heartliver stagnation type were selected from the outpatient department of Department of Cardiology of Cangzhou Hospital of Integrated TCM-WM · Hebei,the patients were divided into control group and experimental group by random number table method,with36 cases in each group.The routine western medicine treatment group was used as the control group,and Tongmai Jieyu Decoction combined with western medicine routine treatment group as the experimental group.The course of clinical observation was 4 weeks.The TCM syndrome scores,angina pectoris symptoms,ECG changes,nitroglycerin stopping rate,High-sensitivity C-reactive protein(hs-CRP),Homocysteine(Hcy),Platelet(PLT),Total cholesterol(TC),Triglyceride(TG),High-density lipoprotein cholesterol(HDL-C),Low-density lipoprotein cholesterol(LDL-C)and safety-related data were observed,and the data were analyzed by SPSS 26.0 statistical software after the experiment.Results A total of 72 qualified cases were included in this study,and one case fell off in each group with a falling-off rate of 2.78%,finally 70 cases were valid data.The data of 70 cases were analyzed,there was no significant difference in gender,age,course of disease and angina grading between the two groups before treatment(P > 0.05).1 TCM syndrome score: after treatment,the total score of TCM syndrome in both groups can be reduced,and the decreasing value of the experimental group was higher than that of the control group(P< 0.05).The effective rate of TCM syndrome in the experimental group(88.57%)was stronger than that in the control group(62.86%)(P < 0.05).2 Angina pectoris score: after treatment,the total score of angina pectoris in both groups can be reduced,and the decrease in the experimental group was higher than that in the control group(P < 0.05).The effective rate of angina pectoris in the experimental group(85.71%)was stronger than that in the control group(62.86%)(P < 0.05).3 ECG effect: The effective rate of ECG improvement in the experimental group(74.29%)was stronger than that in the control group(48.57%)(P < 0.05).4 Nitroglycerin withdrawal rate: The stopping and decreasing rate of nitroglycerin in the experimental group(82.86%)was stronger than that in the control group(60%)(P < 0.05).5 Laboratory indicators: After the completion of the experiment,the levels of hs-CRP,Hcy and PLT in the two groups decreased,and the decreasing values of the three indexes in the experimental group were higher than those in the control group(P < 0.05).6 Comparison of four items of blood lipids: after the completion of the experiment,the levels of TC,TG and LDL-C decreased and the level of HDL-C increased in both groups,but there was no significant difference in the decreasing value of TG between the experimental group and the control group(P > 0.05);The decreasing values of TC and LDL-C and the rising values of HDL-C in the control group were stronger than those in the control group.7 Safety: before and after treatment,heart rate,blood pressure,routine blood urine and stool,Alanine aminotransferase(ALT)and Aspartate aminotransferase(AST)in liver function,Blood urea nitrogen(BUN)and Creatinine(Cr)in renal function were in the normal range,and there were no adverse reactions,so the safety was good.Conclusions Tongmai Jieyu Decoction combined with western medicine routine treatment can effectively improve the TCM syndromes and the angina pectoris symptoms,improve myocardial ischemia,reduce the dosage of nitroglycerin,reduce the levels of hsCRP,Hcy and PLT,and regulate blood lipids.The curative effect is stronger than that of pure western medicine,and there is no obvious adverse reaction,so it is worthy of clinical promotion.Figure 0;Table 15;Reference 104...