Clinical Study On Mazhu Xiongzhi Granule In Treating Children Upper Airway Cough Syndrome Of Wind Pathogen Invading Lung Type

ObjectiveTo observe the clinical efficacy of Mazhu Xiongzhi Granules in the treatment of upper airway cough syndrome in children with wind evil invading lung type,basis for the promotion,application and research of this prescription,and to provide ideas for the development of hospital preparations.MethodsFrom December 2021 to December 2022,children aged 3-14 years old who were diagnosed with upper airway cough syndrome in children with allergic rhinitis were selected from Yantai Hospital of Traditional Chinese Medicine.According to the different medication of Mazhu Xiongzhi Granules and montelukast sodium chewable tablets combined with Tongqiao Biyan Granules,the treatment group and the control group were set up.The treatment group was treated with self-made Mazhu Xiongzhi Granules,and the control group was treated with montelukast sodium chewable tablets combined with Tongqiao Biyan Granules.A total of 64 children were included(The number of cases was calculated by the sample size formula),and 32 children were included in each of the two groups according to the random number table method.After two weeks of treatment,the scores of main symptoms and secondary symptoms before and after treatment were compared between the two groups.SPSS software was used for statistical analysis and conclusions were drawn.ResultsA total of 64 children were included in this study,of which 3 children fell off during the study.Finally,the clinical observation of 61 children was completed,including 30 in the treatment group and 31 in the control group.The clinical data were statistically analyzed.Before treatment,there was no significant difference between the treatment group and the control group in general data(personality,age,course of disease),main symptoms and secondary symptoms(P >0.05).In the treatment of main symptoms,intragroup comparison : there were significant differences in cough and nasal congestion scores between the two groups before and after treatment(P<0.05),indicating that the two groups were effective in treating cough and nasal congestion symptoms in children;comparison between groups :There were significant differences between the two groups in improving cough and nasal congestion symptoms(P <0.05).The results showed that the treatment group had more advantages in treating cough and nasal congestion symptoms.In the treatment of secondary symptoms,intra-group comparison:there were significant differences in expectoration,sneezing,runny nose,nasal itching,throat clearing,postnasal drip and pharyngeal symptom scores between the two groups before and after treatment(P <0.05),indicating that both groups could improve the above symptoms of children.Comparison between groups : There were significant differences between the two groups in improving the symptoms of nasal itching,runny nose and throat clearing(P <0.05),but there was no significant difference in improving the symptoms of expectoration,sneezing,postnasal drip and pharyngeal symptoms(P >0.05).The results showed that the treatment plan of the treatment group had more advantages than the treatment group in the treatment of nasal itching,runny nose and throat clearing.The effective rate of the treatment group was 93.33 %,and the effective rate of the control group was 76.67 %.There was a statistical difference between the two groups(P < 0.05).In terms of safety evaluation,there was no allergy in children.There were no obvious abnormalities in blood,urine,stool routine and liver and kidney function before and after treatment in the treatment group and the control group.The safety of the test was high.ConclusionThe effective rate of Mazhu Xiongzhi granule in the treatment of upper airway cough syndrome in children with wind pathogen invading lung type was higher than that in the control group,and it had obvious advantages in improving the main symptoms(cough,nasal congestion)and secondary symptoms(nasal itching,runny nose,clear throat)compared with the control group.The safety of the scheme was high,and no allergic events observed during the test.The overall effect was ideal,which provided clinical basis for the promotion and application of this prescription and research,and provided ideas and methods for clinical application and hospital preparation.