| Objective:This paper studies the clinical efficacy of Bugan Decoction in the treatment of Parkinson’s patients with Yin deficiency and Yang hyperactivity syndrome,and provides clinical reference for the treatment of Parkinson’s disease with traditional Chinese medicine compound.Methods:According to the inclusion and exclusion criteria of this study,60 PD patients hospitalized in Liuzhou Hospital of Traditional Chinese Medicine from January 2022 to February 2023 were selected and numbered according to the order of treatment.The patients were randomly divided into treatment group and control group by random and controlled research methods,30 cases in each group.The control group was treated with conventional anti-Parkinson’s disease treatment drugs according to the Chinese Parkinson’s disease treatment guidelines(Fourth Edition):Levodopa and Benserazide Tablets(produced by Shanghai Roche Pharmaceutical Co.,Ltd.,trade name Madopar,National Drug License No.:H10930198,dose 250mg/tablet,including levodopa 200mg and benserazide 50mg),initial dose 125mg/time,3times/d;from the second week,the dose was gradually increased according to the patient’s tolerance until the maintenance dose of 750mg/d was reached.Pramipexole tablets(produced by Qilu Pharmaceutical Hainan Co.,Ltd.,trade name Qishuning,national drug approval number:H20203724,dose 0.25 mg/tablet),initial dose 0.125mg/time,3times/d,the second week began to adjust to 0.25mg/time,4 times/d,and then gradually increased the dose according to the patient’s tolerance until the maintenance dose reached 4.5mg/d.Keiselejilan Tablets(produced by Shandong Lvye Pharmaceutical Co.,Ltd.,trade name Jinsiping,national drug approval number:H20133055,dose 5mg/tablet),initial dose 2.5mg/time,2times/d,according to tolerance can be increased to 5mg/time,2 times/d.The original basic diseases(such as hypertension,diabetes,etc.)of the patients were unchanged,and the course of treatment was 2 weeks.The treatment group was treated with oral Bugan Decoction on the basis of western medicine.One pair of water decoction was decocted to 400 ml every day,which was taken twice in the morning and evening.The treatment period was 2 weeks.During the treatment period,the anti-Parkinson’s disease drugs of the two groups remained unchanged.On the first day of enrollment and the 14 th day after treatment,the patients were scored and recorded by the modified Hoehn-Yahr grading scale,the third part of the Unified Parkinson’s Disease Rating Scale(UPDRSIII),the 39-item Parkinson’s Disease Quality of Life Questionnaire(PDQ-39)and the TCM Syndrome Score Scale,a total of 2 times;on the first day and the 14 th day of the patient’s enrollment,5ml of blood was extracted,the serum was separated and cryopreserved,the levels of TNF-α and IL-10 in the serum were detected,and the patient’s vital signs were detected during the medication.Whether there were significant changes in liver and kidney function before and after treatment,and whether the patient had adverse drug reactions.All the data obtained above were uniformly recorded in the Excel table,and the data were analyzed and compared with SPSS26.0 statistical software(P<0.05)to evaluate the therapeutic effect.Results:During the study period,6 cases were lost due to various reasons,so there were 54 cases in this study,27 cases in each group.1.Comparison of general data:There was no significant difference in age,sex and course of disease between the two groups before and after treatment(P>0.05).2.Modified H&Y grading:Before treatment,there was no significant difference in the modified H&Y grading between the two groups(P>0.05).After treatment,the modified H&Y grading of the two groups was lower than that before treatment,and the treatment group decreased more significantly,indicating that the treatment methods of the two groups could improve the symptoms of the patients,and the treatment group was better(P<0.05).3.TCM syndrome score scale:Before treatment,there was no significant difference between the two groups(P>0.05).After treatment,the total scores of TCM syndrome scores in the two groups were lower than those before treatment,and the treatment group decreased more significantly,indicating that the treatment methods of the two groups could improve the clinical symptoms of the patients,and the effect of the treatment group was more significant(P<0.05).4.UPDRSIII score:Before treatment,there was no significant difference in UPDRSIII score between the two groups(P>0.05).After treatment,the UPDRSIII scores of the two groups were lower than those before treatment,and the treatment group decreased more significantly,indicating that the motor function of the two groups was improved,and the treatment group improved more significantly(P<0.05).5.PDQ-39:Before treatment,there was no significant difference in PDQ-39 score between the two groups(P>0.05).After treatment,the scores of PDQ-39 in both groups were lower than those before treatment,and the treatment group decreased more significantly,indicating that the treatment methods of both groups could improve the quality of life of patients,but the treatment group improved more significantly(P<0.05).6.Serum TNF-α and IL-10 factors:Before treatment,there was no significant difference in serum TNF-α and IL-10 factors between the two groups(P>0.05).After treatment,the levels of TNF-α in the two groups were lower than those before treatment,and the decrease in the treatment group was more obvious(P<0.05).After treatment,the levels of IL-10 in the two groups increased,and those in the treatment group increased more significantly(P<0.05).It shows that both treatment methods have an effect on serum TNF-αand IL-10 factors,which can reduce serum TNF-α factor levels and increase serum IL-10 factor levels,and the treatment group has a more obvious effect on serum factors.7.In terms of overall effective rate:both groups were effective after treatment compared with before treatment.The number of effective cases in the treatment group was 26,and the effective rate was 96.3%(P<0.05).There were 20 cases in the control group,with an effective rate of 74.1%(P<0.05),and the treatment group was more effective.Conclusion:1.Bugan decoction can improve the clinical symptoms,physical and mental health and quality of life of PD patients with yin deficiency and yang hyperactivity,and its therapeutic effect is better than that of western medicine alone.2.The effect of Bugan Decoction on PD may be related to the increase of serum IL-10 level and the decrease of serum TNF-α level,and its mechanism may be related to the inflammatory response in PD patients. |
PDF Full Text Request