A Intervention Study On Levels Of Oxidative Stress And Inflammatory Factors In Overweight And Obesity

ObjectivesOverweight and obesity have become a serious public health problem.Unhealthy dietary patterns and lack of exercise are important factors in the occurrence of overweight and obesity.Overweight and obesity are risk factors for many chronic diseases.Elevated levels of oxidative stress and inflammation may play a role in the persistence of these chronic diseases.In this study,the oxidative stress level of overweight and obese people was interfered with by exercise and/or antioxidant intervention,and to explore the intervention measures to alleviate oxidative stress and inflammatory factors levels in overweight and obese patients.The results will provide relevant scientific data for the development of health interventions for this population.MethodsThe subjects were overweight/obese undergraduates attending Dali University.Subjects were randomly divided into control group(zero intervention group),exercising(walking)group,taking vitamin C(Vit C)group,exercising(walking)+Vit C group(combined intervention group).The intervention study(Run 0-Run 1-Run 2)lasted for two weeks.The physical indices Body mass index(BMI),waist circumference,serum reactive oxygen species(ROS),tumor necrosis factor alfa(TNF-α),interleukin-1beta(IL-1β)and urinary8-hydroxy-2-deoxyguanosine(8-OHd G).These measures were repeated three times.Building database was by Excel 2019.Statistical analysis was performed by SPSS25.0 and Graph Pad Prism7.0.Results82 participants actually entered the study,5withdrew halfway,leaving 77 to complete the study.The results of intervention(1)Exercising significantly alleviated ROS levels,and this was consistent in Run 1 and Run 2(P<0.01).(2)Exercising,taking Vit C,exercising + taking Vit C all reduced 8-OHd G levels after one week of intervention.Although there was an increase in 8-OHd G level during Run 2,there was no statistical significance.(3)The alleviating effects of three intervention modes on TNF-α during Run1 and Run2 were not observed;(4)Throughout the intervention period,the three intervention modes had significant remission effects on IL-1β levels.ConclusionEven short-term exercising and taking Vit C can reduce the level of ROS,8-OHd G and IL-1β,but not for TNF-α,in overweight subjects,even in.These interventions could be potential preventative measures for overweight against the oxidative stress and inflammation caused by obesity(P<0.05).