| Object: acute gastric pain is a common disease in clinic, which includes sudden stomach pain caused by gastric ulcer, duodenal ulcer, acute gastritis, gastric spasm in western medicine. Antispasmodic is used in western medicine, but it has side-effects such as dry mouth, blurred vision and tachycardia etc. TCM has the advantage of better curative effect and fewer side-effects. So it is an important task to find high-effect herbs without side-effects.Pathogenesis of acute gastric pain is Qi-stagnation of stomach. So based on the principle of promoting the flow of Qi and regulating stomach, Liqiheweikoufuye is established. Liqiheweikoufuye is better than 654-2 in aspects of curative effect and relieving pain in clinic. Based on previous research, we further explore its mechanism.Method:Measure LD50 and maxim dosageObserve its influence on acute inflammationObserve its influence on healing of gastric ulcerObserve its influence onmucosa repair of acute gastric ulcerObserve its protection of mucosa from acute lesionObserve its influence on movement of small intestineObserve its influence on peristalsisResult:No animal died during experiment, so LD50 can not be measured. The maxim dosage is 60ml/kg, which is 634 times of clinical dosage.High and medium dosages of Liqiheweikoufuye can raise the pain threshold of rats.Liqiheweikoufuye can alleviate inflammation of rats, which indicates it has the function of anti-inflammation.High dosage of Liqiheweikoufuye can improve ulcer area and ulcer index.Liqiheweikoufuye can alleviate acute gastric mucosa lesion.Liqiheweikoufuye can promote the healing of gastric ulcer.Liqiheweikoufuye can promote the movement of small intestine.Liqiheweikoufuye can inhibit the spasm of intestinal smooth muscle.Conclusion:Liqiheweikoufuye has the function of analgesia, anti-inflammation, anti-ulcer. It can promote the healing of ulcer, alleviate acute lesion of mucosa. It can promote peristalsis and inhibit spasm of intestinal smooth muscle.
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